Differentially expressed serum host proteins in hepatitis B and C viral infections
| Autor: | Rahul Chavan, Shobna Bhatia, Bhavik Dalal, Akash Shukla, Kruti Dalal, Priyanka Khorate, Avinash Kale, Aruna Shankarkumar |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Hepatitis Hepatitis B virus business.industry Hepatitis C virus Hepatitis C Hepatitis B medicine.disease medicine.disease_cause Virology digestive system diseases 03 medical and health sciences Retinol binding protein 030104 developmental biology 0302 clinical medicine Infectious Diseases 030220 oncology & carcinogenesis Hepatocellular carcinoma medicine Original Article Viral hepatitis business |
| Zdroj: | Virusdisease. 29(4) |
| ISSN: | 2347-3584 |
| Popis: | Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infection often lead to hepatocellular carcinoma (HCC), which is mostly detected in advanced stage. Hence, its early detection is of paramount importance using a biomarker having sensitivity and specificity both. The present study highlights differentially expressed host proteins in response to HBV/HCV infection at different stages. Comparative proteomic study was done by two-dimensional gel electrophoresis followed by mass spectrometry. Sera from each of chronically infected, liver cirrhosis and HCC in HBV or HCV infection along with controls were selected. Analysis of functional association between differentially expressed proteins with viral hepatitis was extensively carried out. Forty-three differentially expressed spots (≥ 1.5 fold; P |
| Databáze: | OpenAIRE |
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