Targeting estrogen receptors in colorectal cancer
| Autor: | Endong Bao, Shu Tang, Joyce Wanjiru Maingi, Watson Ngenya, Sirui Liu |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Colon medicine.drug_class Colorectal cancer Estrogen receptor Phytoestrogens Bioinformatics Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Genetics medicine Estrogen Receptor beta Humans Intestinal Mucosa Adverse effect Molecular Biology Estrogen receptor beta business.industry Estrogen Receptor alpha Estrogens General Medicine medicine.disease Gene Expression Regulation Neoplastic 030104 developmental biology Receptors Estrogen chemistry Estrogen 030220 oncology & carcinogenesis Colonic Neoplasms Female Colorectal Neoplasms business Signal Transduction Hormone |
| Zdroj: | Molecular Biology Reports. 47:4087-4091 |
| ISSN: | 1573-4978 0301-4851 |
| DOI: | 10.1007/s11033-020-05414-6 |
| Popis: | Hormones have become a useful therapeutic aspect of clinical endocrinology but how to use them to optimize the health benefits and avoid adverse effects is a major challenge. Estrogen is an indispensable hormone for proper biological functioning but is also implicated with the pathology of both the reproductive and non-reproductive tissues. Abnormal estrogen receptor signaling may increase the risk of development of a variety of diseases including colorectal cancer (CRC). Estrogen receptor beta (ERβ) is the predominant subtype in the colonic epithelium and confers the anti-tumor effect through various mechanisms. Many investigators have embarked on the search for the biological mechanisms by which estrogen and estrogen-like compounds may influence the pathogenesis of CRC. This review explores the recent findings on the therapeutic role of ERβ in the colonic epithelium as a prospective candidate for targeted endocrine therapy in CRC. |
| Databáze: | OpenAIRE |
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