CSF viral escape in a patient with HIV-associated neurocognitive disorder
| Autor: | Michael N. Khoury, C. Sabrina Tan, Igor J. Koralnik, Marcia Peaslee |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Pathology Neurology HIV Infections Inflammation Biology HIV-associated neurocognitive disorder Blood–brain barrier Antiviral Agents Article Virus Young Adult Cellular and Molecular Neuroscience Virology medicine Humans Young adult Brain Diseases Microglia Viral Load medicine.disease medicine.anatomical_structure Immunology Female Neurology (clinical) medicine.symptom Viral load |
| Zdroj: | Journal of NeuroVirology. 19:402-405 |
| ISSN: | 1538-2443 1355-0284 |
| DOI: | 10.1007/s13365-013-0175-9 |
| Popis: | HIV associated neurocognitive disorder (HAND) is a condition that encompasses cognitive deficits as well as motor symptoms. HIV is thought to enter the CNS early at the time of primary infection by crossing the blood brain barrier. The virus primarily infects perivascular macrophages and microglia (both of which express CD4); while the neurons, which do not express CD4, sustain injury secondary to the resulting inflammation(Gonzalez-Scarano and Martin-Garcia 2005). HAND MRI findings classically include symmetric, periventricular hyperintense lesions on T2-weighted sequences. We describe an HIV+ patient with an absolute CD4+ T-cell count in the normal range and well-controlled plasma HIV viral load (vl) who developed progressive cognitive decline and gait difficulty. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink