Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes
| Autor: | Donald W. Graff, Carl D. D’Ruiz, X. Sherwin Yan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Nicotine medicine.medical_treatment Smoking Prevention Craving Electronic Nicotine Delivery Systems Dizziness law.invention Plasma nicotine Randomized controlled trial Crossover study law Tobacco Humans Medicine Pharmacokinetics Single-Blind Method Smoking urge Adverse effect Throat irritation Cross-Over Studies business.industry Smoking Headache Public Health Environmental and Occupational Health Pharyngitis Tobacco Products Tobacco Use Disorder Middle Aged Tolerability Clinical trial Menthol Pharmacodynamics Cough Electronic cigarettes Adverse events Anesthesia Smoking cessation Female Smoking Cessation medicine.symptom business Research Article medicine.drug |
| Zdroj: | BMC Public Health |
| ISSN: | 1471-2458 0221-0754 |
| DOI: | 10.1186/s12889-015-2349-2 |
| Popis: | This randomized, partially single-blinded, 6-period crossover clinical study of adult smokers compared the nicotine pharmacokinetics, impacts on smoking urge and tolerability of various formulations of one brand of e-cigarettes with that of a tobacco cigarette. Five e-cigarettes with different e-liquid formulations containing 1.6 % and 2.4 % nicotine and a conventional tobacco cigarette were randomized among 24 subjects under two exposure sessions consisting of a 30-min controlled and a one-hour ad lib use period to assess plasma nicotine levels, impacts on smoking urge and adverse events. The 30-min controlled use session comprised an intensive use of the e-cigarettes with a total of 50 puffs taken every 30 s for comparison to a single conventional cigarette having a typical machine-measured nicotine yield (~0.8 mg). Ad lib product use conditions provided insight into more naturalistic product use behaviors and their accompanying smoking urge reductions. Adverse events (AEs) were assessed by the Principal Investigator. Significant (p |
| Databáze: | OpenAIRE |
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