Cognitive Efficacy of Quetiapine and Olanzapine in Early-Onset First-Episode Psychosis
| Autor: | Celso Arango, Dolores Moreno, Ana Ruiz-Sancho, Mara Parellada, Igor Bombin, Arantzazu Zabala, Olalla Robles |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Olanzapine Dibenzothiazepines Pediatrics medicine.medical_specialty Psychosis Bipolar Disorder Adolescent Psychometrics medicine.drug_class Atypical antipsychotic Neuropsychological Tests law.invention Benzodiazepines Quetiapine Fumarate Randomized controlled trial law medicine Humans Single-Blind Method Psychiatry First episode Dopamine antagonist medicine.disease Psychiatry and Mental health Treatment Outcome Psychotic Disorders Spain Schizophrenia Quetiapine Female Schizophrenic Psychology Cognition Disorders Psychology Regular Articles Antipsychotic Agents Follow-Up Studies medicine.drug |
| Zdroj: | Schizophrenia Bulletin. 37:405-415 |
| ISSN: | 1745-1701 0586-7614 |
| Popis: | The primary purpose of this study was to compare changes in cognition in early-onset psychosis after 6-months treatment with quetiapine or olanzapine. This is a randomized, single-blind, 6-month study in 50 adolescents with a diagnosis of early-onset psychosis. Patients were randomized to quetiapine (n = 24) or olanzapine (n = 26). A thorough neuropsychological battery was administered at baseline and after 6-month treatment. Out of the total sample included in the study, 32 patients completed at least 6-months treatment with the assigned medication (quetiapine, n = 16; olanzapine, n = 16). No changes were observed in cognitive performance after 6-month treatment with quetiapine or olanzapine. Although some trends toward cognitive improvement were observed for the olanzapine group after 6-month treatment, neither group showed statistically significant gains. Furthermore, there was no evidence of any differential efficacy of olanzapine or quetiapine on cognitive improvement in this sample of adolescents with psychosis. |
| Databáze: | OpenAIRE |
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