Effects of Sleep Deprivation, Nicotine, and Selenium on Wound Healing in Rats
| Autor: | Erhan Varoglu, Bedri Seven, Omer Aktas, Senol Dane, Mustafa Keles, Nesrin Gürsan, Kenan Gumustekin, Sahin Aslan, Nezihe Karabulut |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Nicotine medicine.medical_specialty Neutrophils Neovascularization Physiologic medicine.disease_cause Antioxidants Rats Sprague-Dawley Neovascularization Lipid peroxidation Selenium chemistry.chemical_compound Internal medicine medicine Medicine and Health Sciences Animals Drug Interactions Nicotinic Agonists Fibroblast Skin Wound Healing integumentary system business.industry General Neuroscience General Medicine Fibroblasts medicine.disease Privation Rats Disease Models Animal Sleep deprivation Endocrinology medicine.anatomical_structure Radioimmunodetection chemistry Immunoglobulin G Anesthesia Sleep Deprivation medicine.symptom business Wound healing Oxidative stress medicine.drug |
| DOI: | 10.17605/osf.io/jshra |
| Popis: | Effects of sleep deprivation (SD), nicotine, and selenium (Se) on wound healing were studied in 50 male rats (Sprague-Dawley strain). Full-skin-thickness burns were produced in animals. Then, SD, nicotine, and Se administrations were applied to animals in different groups. Wound healing was assessed by pathological analysis of wound by counting fibroblasts, capillary vessels, polymorphonuclear leucocytes (PNLs), and by measuring radiolabeled immunoglobulin G (IgG) amount in wound area by radio-pharmaceutical and immunoscintigraphic procedures. The number of fibroblasts and capillary vessels were higher in control and Se groups than in sleep deprivation and nicotine groups, and the number of PNLs and the radiolabeled polyvalent IgG levels were higher in SD and nicotine groups than in control and Se groups. The results suggest that SD and nicotine may delay wound healing and that Se supplementation may accelerate wound healing by preventing nicotine-induced oxidative stress and lipid peroxidation. |
| Databáze: | OpenAIRE |
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