Long-term metabolic control in recipients of combined pancreas and kidney transplants
| Autor: | Øystein Bentdal, O Djøseland, Idunn Brekke, Hallvard Holdaas, K. J. Berg, A. Gjellestad, Audun Flatmark, T. Ganes, Anders Hartmann, Jak Jervell, P. Fauchald |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Physiology Pancreas transplantation Biology Glucagon Reference Values Internal medicine Internal Medicine medicine Humans Diabetic Nephropathies Kidney transplantation Uremia Glycated Hemoglobin Glucose tolerance test Kidney C-Peptide medicine.diagnostic_test Glucose Tolerance Test medicine.disease Kidney Transplantation Transplantation Diabetes Mellitus Type 1 medicine.anatomical_structure Endocrinology Metabolic control analysis Pancreas Transplantation Immunosuppressive Agents Follow-Up Studies |
| Zdroj: | Diabetologia. 34:S68-S70 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/bf00587623 |
| Popis: | Metabolic glucose control was followed in 36 patients at 12-month intervals for up to 5 years after a successful combined kidney and segmental duct-occluded pancreas transplantation. All recipients had normal blood glucose levels at each examination. HbA1 values, intravenous glucose tolerance test, C-peptide levels and C-peptide responses to glucagon stimulation were also, on average, within the normal range. Several individual patients had, however, abnormal values for these parameters. At most 46% had abnormal values for HbA1 and intravenous glucose tolerance test, up to 13% showed low C-peptide values and up to 46% of the stimulated C-peptide responses were inadequate at the different intervals. These parameters did not deteriorate with time. This was true both for the whole group of patients as well as for the 6 patients with a 5-year observation time evaluated separately. Despite these abnormalities in glucose metabolism, all patients remained normoglycaemic without need for exogenous insulin up to 5 years after transplantation. The long-term ability of duct-occluded segmental pancreatic grafts to preserve euglycaemia therefore seems to remain intact at least for 5 years. |
| Databáze: | OpenAIRE |
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