The impact of single versus mixed schistosome species infections on liver, spleen and bladder morbidity within Malian children pre- and post-praziquantel treatment

Autor: Mamadou Traoré, Robert Dembelé, Adama D. Keita, Joanne P. Webster, Christl A. Donnelly, Anouk N. Gouvras, Moussa Sacko, Artemis Koukounari, Elisa Bosqué-Oliva, Albis Francesco Gabrielli, Aly Landouré, Alan Fenwick
Přispěvatelé: Medical Research Council (MRC)
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Male
OFFICE-DU-NIGER
DT Africa
Comorbidity
R Medicine (General)
IRRIGATION SCHEME
Mali
Praziquantel
Medical microbiology
1108 Medical Microbiology
Epidemiology
EPIDEMIOLOGY
Schistosomiasis
MATING INTERACTIONS
Child
Schistosoma haematobium
Anthelmintics
Urinary bladder
biology
SCHOOLCHILDREN
INFECTIOUS DISEASES
Schistosoma mansoni
HAEMATOBIUM INFECTION
medicine.anatomical_structure
Liver
Female
Life Sciences & Biomedicine
medicine.drug
Research Article
0605 Microbiology
AFRICA
medicine.medical_specialty
Adolescent
TRANSMISSION
Urinary Bladder
MANSONI
Microbiology
lcsh:Infectious and parasitic diseases
Internal medicine
parasitic diseases
medicine
Animals
Humans
lcsh:RC109-216
Schistosoma
Science & Technology
AREA
1103 Clinical Sciences
biology.organism_classification
medicine.disease
Immunology
Spleen
Zdroj: BMC Infectious Diseases
BMC Infectious Diseases, Vol 10, Iss 1, p 227 (2010)
ISSN: 1471-2334
Popis: Background In the developing world co-infections and polyparasitism within humans appear to be the rule rather than the exception, be it any combination of inter-specific and/or inter- and intra-Genera mixed infections. Mixed infections might generate synergistic or antagonistic interactions and thereby clinically affect individuals and/or impact parasite epidemiology. Methods The current study uniquely assesses both Schistosoma mansoni- and Schistosoma haematobium-related morbidity of the liver and the bladder as assessed by ultrasound as well as spleen and liver morbidity through clinical exams. The impact of praziquantel (PZQ) treatment on such potential inter-specific schistosome interactions and resulting morbidity using uniquely detailed longitudinal data (pre- and one year post-PZQ treatment) arising from the National Schistosomiasis Control Program in three areas of Mali: Ségou, Koulikoro and Bamako, is also evaluated. At baseline, data were collected from up to 2196 children (aged 7-14 years), 844 of which were infected with S. haematobium only, 124 with S. mansoni only and 477 with both. Follow-up data were collected from up to 1265 children. Results Results suggested lower liver morbidity in mixed compared to single S. mansoni infections and higher bladder morbidity in mixed compared to single S. haematobium infections. Single S. haematobium or S. mansoni infections were also associated with liver and spleen morbidity whilst only single S. haematobium infections were associated with bladder morbidity in these children (light S. haematobium infection OR: 4.3, p < 0.001 and heavy S. haematobium infection OR: 19, p < 0.001). PZQ treatment contributed to the regression of some of the forms of such morbidities. Conclusions Whilst the precise biological mechanisms for these observations remain to be ascertained, the results illustrate the importance of considering mixed species infections in any analyses of parasite-induced morbidity, including that for the proposed Disability Adjusted Life Years (DALYs) revised estimates of schistosomiasis morbidity.
Databáze: OpenAIRE
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