Laser Doppler Flowmetry in Lower Extremity Ischemia: Application and Interpretation
| Autor: | Lea Zulty, Michaela Modan, Arie Bass, Raphael Walden, Moshe Balaciano, Raphael Adar |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Ischemia Hyperemia Physical examination Sensitivity and Specificity Internal medicine Laser-Doppler Flowmetry medicine Humans Pulse wave Cutoff Reactive hyperemia Aged Skin Peripheral Vascular Diseases Leg medicine.diagnostic_test business.industry Reproducibility of Results General Medicine Blood flow Middle Aged Laser Doppler velocimetry medicine.disease Capillaries Surgery Arterioles Amplitude Cardiology Female Cardiology and Cardiovascular Medicine business Blood Flow Velocity |
| Zdroj: | Annals of Vascular Surgery. 6:511-516 |
| ISSN: | 0890-5096 |
| DOI: | 10.1007/bf02000822 |
| Popis: | The present study was undertaken in order to develop numerical criteria for the parameters of laser Doppler flowmetry-skin blood flow velocity and pulse wave amplitude in the evaluation of lower extremity ischemia. Fifty limbs of young healthy volunteers were examined in order to obtain baseline normal values. Patient population was divided into moderately ischemic (52 limbs) and severely ischemic (22 limbs), based on patients' complaints, physical examination, ankle-brachial indices, pulse volume recordings and arteriographies. Univariate comparison between the three groups of skin blood flow velocity and pulse wave amplitude at each time point were done by analysis of variance. Power of discrimination between degrees of ischemia was evaluated by computing sensitivity and specificity, based on skin blood flow velocity and pulse wave amplitude values at time points best for predicting the severity of disease by multiple regression analysis. Using cutoff points of < 31 for skin blood flow velocity and < 9 for pulse wave amplitude, a 96% sensitivity and 96% specificity were obtained in separating normal from ischemic limbs. Cutoff points of < 9 for skin blood flow velocity and < 4 for pulse wave amplitude discriminated with a 100% sensitivity and specificity between the moderately and severely ischemic limbs. We propose the use of laser Doppler flowmetry with local heating and reactive hyperemia, and the cutoff points stated above as an additional tool to evaluate lower extremity ischemia through assessment of cutaneous microcirculation. |
| Databáze: | OpenAIRE |
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