Nepetifoliol - a new glutinane-triterpenoid from Leonotis nepetifolia
Autor: | Thi-Le-Thuy Nguyen, Thi-Hoai-Thu Nguyen, That-Quang Ton, Kim-Phi-Phung Nguyen, Thi-Thuy-Duong Ngo, Thi-Kim-Huong Nguyen, Thanh-Tung Phan |
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Rok vydání: | 2021 |
Předmět: |
chemistry.chemical_classification
biology Stereochemistry Organic Chemistry Friedelin Positive control Plant Science Leonotis nepetifolia biology.organism_classification Biochemistry Nmr data Analytical Chemistry chemistry.chemical_compound Triterpenoid Triterpene chemistry medicine Ic50 values Acarbose medicine.drug |
DOI: | 10.6084/m9.figshare.15134181.v1 |
Popis: | A new glutinane-triterpenoid, nepetifoliol (1), together with two known compounds, dymacrin D (2), and (+)-ar-tumerone (3) were isolated from the n-hexane extract of the aerial parts of Leonotis nepetifolia. Their chemical structures were elucidated by spectroscopic data analysis as well as the comparison of their NMR data with the ones published in the literatures. A putative biosynthetic pathway for the formation of the new compound (anti-diaxial-5,6-diol) (1) from the precursor triterpene glutinol was proposed. Compounds (2), (3) and some previously reported ones, isolated from this extract, including 5α-stigmasta-22-ene-3-one (4), friedelin (5), chrysophanol (6), physcion (7), and 4'-O-methylalpinumisoflavone (8) were evaluated for their α-glucosidase inhibition. Among tested compounds, 3 and 6 showed good activities with their IC50 values of 5.3 ± 0.2 and 4.9 ± 0.3 µg/mL, respectively, comparing to the positive control, acarbose (IC50 127.7 ± 0.2 µg/mL). |
Databáze: | OpenAIRE |
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