Acute contractile recovery extent during biventricular pacing is not associated with follow-up in patients undergoing resynchronization

Autor: Paolo Marino, Eraldo Occhetta, Virginia Di Ruocco, Chiara Cavallino, Emanuela Facchini, Chiara Sartori, Anna Degiovanni, Andrea Magnani, Federica Devecchi, Matteo Santagostino
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Inotrope
Congestive heart failure
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Cardiac & Cardiovascular Systems
r2
adjusted r squared
Speckle tracking echocardiography
030204 cardiovascular system & hematology
EDV
end-diastolic volume
MR
mitral regurgitation
Article
03 medical and health sciences
QRS complex
0302 clinical medicine
Internal medicine
Heart rate
medicine
EF
ejection fraction
030212 general & internal medicine
cardiovascular diseases
Ejection fraction
business.industry
FFR
force–frequency relation
Force–frequency relation
Speckle-tracking echocardiography
CRT
biventricular stimulation
TUS
temporal uniformity of strain
Ea
arterial elastance
HR
hazard ratio
Dyssynchrony
Blood pressure
LV
left ventricle
lcsh:RC666-701
Cardiology
cardiovascular system
End-diastolic volume
Dobutamine
DYS
dyssynchrony
Resynchronization
Cardiology and Cardiovascular Medicine
business
Ees
ventricular elastance
medicine.drug
Zdroj: International Journal of Cardiology: Heart & Vasculature, Vol 11, Iss C, Pp 66-73 (2016)
International Journal of Cardiology. Heart & Vasculature
Scipedia Open Access
Scipedia SL
ISSN: 2352-9067
Popis: Background: It has been reported that contractility, as assessed using dobutamine infusion, is independently associated with reverse remodeling after CRT. Controversy, however, exists about the capacity of this approach to predict a long-term clinical response. This study's purpose was to assess whether long-term CRT clinical effects can be predicted according to acute inotropic response induced by biventricular stimulation (CRT on), as compared with AAI–VVI right stimulation pacing mode (CRT off), quantified at the time of implantation. Methods: In 98 patients (ejection fraction 29 ± 10%), acute changes in left ventricular (LV) elastance (Ees), arterial elastance (Ea), and Ees/Ea, as assessed from slope changes of the force–frequency relation obtained when the heart rate increased, and also assessed while measuring triplane LV volumes and continuous noninvasive blood pressure, were related to death or rehospitalization during a 3-year follow-up. Other covariances tested were age, gender, disease etiology, QRS duration, amount of mitral regurgitation, LV diastolic volume, ejection fraction, and the degree of asynchrony and longitudinal strain at baseline. Results: There was a marked increment in the Ees slope with CRT (interaction P = 0.004), no Ea change, and modest Ees/Ea increase (interaction P
Databáze: OpenAIRE
Externí odkaz: