Plasma big endothelin-1 levels at admission and future cardiovascular outcomes: A cohort study in patients with stable coronary artery disease
| Autor: | Chuan-Jue Cui, Yuan-Lin Guo, Jian-Jun Li, Ping Qing, Bing-Yang Zhou, Qian Dong, Yao Wang, Rui Xia Xu, Na-Qiong Wu, Xiao-Lin Li, Jing Sun, Cheng-Gang Zhu, Ying Gao, Geng Liu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Acute coronary syndrome medicine.medical_treatment Coronary Artery Disease Kaplan-Meier Estimate 030204 cardiovascular system & hematology Cohort Studies Coronary artery disease 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Myocardial infarction Stroke Aged Proportional Hazards Models Endothelin-1 business.industry Hazard ratio Percutaneous coronary intervention Middle Aged medicine.disease Confidence interval Hospitalization 030104 developmental biology Cardiology Female Cardiology and Cardiovascular Medicine business Cohort study |
| Zdroj: | International Journal of Cardiology. 230:76-79 |
| ISSN: | 0167-5273 |
| Popis: | Background Big endothelin-1 (ET-1) has been proposed as a novel prognostic indicator of acute coronary syndrome, while its predicting role of cardiovascular outcomes in patients with stable coronary artery disease (CAD) is unclear. Methods and results A total of 3154 consecutive patients with stable CAD were enrolled and followed up for 24months. The outcomes included all-cause death, non-fatal myocardial infarction, stroke and unplanned revascularization (percutaneous coronary intervention and coronary artery bypass grafting). Baseline big ET-1 was measured using sandwich enzyme immunoassay method. Cox proportional hazard regression analysis and Kaplan–Meier analysis were used to evaluate the prognostic value of big ET-1 on cardiovascular outcomes. One hundred and eighty-nine (5.99%) events occurred during follow-up. Patients were divided into two groups: events group ( n =189) and non-events group ( n =2965). The results indicated that the events group had higher levels of big ET-1 compared to non-events group. Multivariable Cox proportional hazard regression analysis showed that big ET-1 was positively and statistically correlated with clinical outcomes (Hazard Ratio: 1.656, 95% confidence interval: 1.099–2.496, p =0.016). Additionally, the Kaplan–Meier analysis revealed that patients with higher big ET-1 presented lower event-free survival ( p =0.016). Conclusions The present study firstly suggests that big ET-1 is an independent risk marker of cardiovascular outcomes in patients with stable CAD. And more studies are needed to confirm our findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect