Bioactive natural products from Papua New Guinea marine sponges
| Autor: | Jeffery C. Noro, Brett A. Neilan, John A. Kalaitzis |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Marine sponges
Biological Products biology Ecology Polyketide biosynthesis New guinea Bioengineering General Chemistry General Medicine biology.organism_classification Biochemistry Peptides Cyclic Natural (archaeology) Porifera Sponge Papua New Guinea Drug development Depsipeptides Molecular Medicine Animals Natural Product Research Symbiosis Molecular Biology Oligopeptides |
| Zdroj: | Chemistrybiodiversity. 9(10) |
| ISSN: | 1612-1880 |
| Popis: | The discovery of novel natural products for drug development relies heavily upon a rich biodiversity, of which the marine environment is an obvious example. Marine natural product research has spawned several drugs and many other candidates, some of which are the focus of current clinical trials. The sponge megadiversity of Papua New Guinea is a rich but underexplored source of bioactive natural products. Here, we review some of the many natural products derived from PNG sponges with an emphasis on those with interesting biological activity and, therefore, drug potential. Many bioactive natural products discussed here appear to be derived from non-ribosomal peptide and polyketide biosynthesis pathways, strongly suggesting a microbial origin of these compounds. With this in mind, we also explore the notion of sponge-symbiont biosynthesis of these bioactive compounds and present examples to support the working hypothesis. |
| Databáze: | OpenAIRE |
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