C-reactive protein and albumin kinetics before community-acquired bloodstream infections- A Danish population-based cohort study
| Autor: | Thøger Gorm Jensen, Pernille Just Vinholt, Annmarie Touborg Lassen, Olav Sivertsen Garvik, Court Pedersen, Hans Jørn Kolmos, Bjarne Magnussen, Pedro Póvoa, Kim Oren Gradel |
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| Přispěvatelé: | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty community acquired bloodstream infections Adolescent Danish population Epidemiology Denmark Population Bacteremia Gastroenterology Infectious Disease Incubation Period C-reactive protein Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Internal medicine Bloodstream infection medicine Humans 030212 general & internal medicine education Serum Albumin Aged Aged 80 and over Original Paper education.field_of_study biology business.industry Albumin Middle Aged Community-Acquired Infections Infectious Diseases 030228 respiratory system biology.protein Biomarker (medicine) Female business Biomarkers Cohort study |
| Zdroj: | Garvik, O S, Póvoa, P, Magnussen, B, Vinholt, P J, Pedersen, C, Jensen, T G, Kolmos, H J, Lassen, A T & Gradel, K O 2020, ' C-reactive protein and albumin kinetics before community-acquired bloodstream infections-A Danish population-based cohort study ', Epidemiology and Infection, vol. 148, e38 . https://doi.org/10.1017/S0950268820000291 Epidemiology and Infection |
| DOI: | 10.1017/S0950268820000291 |
| Popis: | Early changes in biomarker levels probably occur before bloodstream infection (BSI) is diagnosed. However, this issue has not been fully addressed. We aimed at evaluating the kinetics of C-reactive protein (CRP) and plasma albumin (PA) in the 30 days before community-acquired (CA) BSI diagnosis. From a population-based BSI database we identified 658 patients with at least one measurement of CRP or PA from day −30 (D–30) through day −1 (D–1) before the day of CA-BSI (D0) and a measurement of the same biomarker at D0 or D1. Amongst these, 502 had both CRP and PA measurements which fitted these criteria. CRP and PA concentrations began to change inversely some days before CA-BSI diagnosis, CRP increasing by day −3.1 and PA decreasing by day −1.3. From D–30 to D–4, CRP kinetics (expressed as slopes – rate of concentration change per day) was −1.5 mg/l/day. From D–3 to D1, the CRP slope increased to 36.3 mg/l/day. For albumin, the slope between D–30 to D–2 was 0.1 g/l/day and changed to −1.8 g/l/day between D–1 and D1. We showed that biomarker levels begin to change some days before the CA-BSI diagnosis, CRP 3.1 days and PA 1.3 days before. |
| Databáze: | OpenAIRE |
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