Gammaherpesvirus targets peritoneal B-1 B cells for long-term latency
| Autor: | Philip T. Lange, Eric J. Darrah, Michaela M. Rekow, Wadzanai P. Mboko, Vera L. Tarakanova |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
viruses B-Lymphocyte Subsets Spleen Biology Article Mice 03 medical and health sciences Gammaherpesvirinae Peritoneum hemic and lymphatic diseases Virology Virus latency medicine Animals Myeloid Cells Latency (engineering) B cell Virus Activation virus diseases Herpesviridae Infections biochemical phenomena metabolism and nutrition respiratory system medicine.disease biology.organism_classification Virus Latency Mice Inbred C57BL Chronic infection 030104 developmental biology medicine.anatomical_structure Host-Pathogen Interactions Immunology |
| Zdroj: | Virology. 492:140-144 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2016.02.022 |
| Popis: | Gammaherpesviruses establish life-long infection in most adults and are associated with the development of B cell lymphomas. While the interaction between gammaherpesviruses and splenic B cells has been explored, very little is known about gammaherpesvirus infection of B-1 B cells, innate-like B cells that primarily reside in body cavities. This study demonstrates that B-1 B cells harbor the highest frequency of latently infected cells in the peritoneum throughout chronic infection, highlighting a previously unappreciated feature of gammaherpesvirus biology. |
| Databáze: | OpenAIRE |
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