The Correction of Facial Morphea Lesions by Hyaluronic Acid: A Case Series and Literature Review
| Autor: | Waldemar Placek, Magdalena Krajewska-Włodarczyk, Agata Bechtold, Agnieszka Owczarczyk-Saczonek, Paulina Klimek, Marta Kasprowicz-Furmańczyk, Anna Kruszewska |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Hyaluronic acid Connective tissue Dermatology Scleroderma Extracellular matrix 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fractional ablative laser medicine Case Series Localized Scleroderma business.industry Correction medicine.disease FAL Morphea Plastic surgery medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis RL1-803 Oral and maxillofacial surgery business |
| Zdroj: | Dermatology and Therapy Dermatology and Therapy, Vol 10, Iss 6, Pp 1423-1434 (2020) |
| ISSN: | 2193-8210 |
| Popis: | Introduction The aim of the study is to assess the long-term safety and efficacy of hyaluronic acid (HA) administration in correction of facial morphea lesions and to review the literature on the subject. Morphea is a chronic inflammatory disease of the connective tissue which may lead to serious deformations. The lesions located on the face particularly affect patients’ quality of life and self-esteem; thus, there is a demand for safe and effective methods of treatment. Case Presentation The paper presents three female patients aged 16, 17 and 70 with facial morphea lesions who had HA preparation Juvéderm® Voluma or Volux, Vycross® technology, Allergan, injected. One of the patients had additionally fractional ablative CO2 laser (FAL) therapy. Discussion The literature provides reports on successful use of HA, polymethylmethacrylate and poly-l-lactic acid for the correction of facial defects in localized scleroderma. HA is a natural component of the extracellular matrix and it therefore minimizes the probability of immunogenicity. The application technique also plays an important role. On the other hand, FAL therapy leads to the degradation of the abnormal collagen and the induction of normal collagen synthesis. Conclusions HA injection and combination of HA application with FAL are minimally invasive, effective and safe therapeutic options for patients suffering from morphea. |
| Databáze: | OpenAIRE |
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