Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice
| Autor: | Youhei Mantani, Mizuki Maeda, Misaki Nishi, Midori Murata, Nobuhiko Hoshi, Asuka Shoda, Sayaka Kitauchi, Yoshinori Ikenaka, Toshifumi Yokoyama, Yoshiaki Tabuchi, Tetsushi Hirano |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
No-observed-adverse-effect level 040301 veterinary sciences Physiology Hippocampal formation Biology Toxicology clothianidin Guanidines 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Mice Neonicotinoids Juvenile Animals behavioral test Pesticides 030304 developmental biology 0303 health sciences Fetus No-Observed-Adverse-Effect Level General Veterinary Dentate gyrus Neurogenesis Neonicotinoid Clothianidin 04 agricultural and veterinary sciences Note Infectious Disease Transmission Vertical Thiazoles developmental stage neurogenesis chemistry Dentate Gyrus fetal and lactational exposure Female |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 0916-7250 |
| Popis: | Recently, it has been reported that neonicotinoid pesticides (NNs) are transferred from mother to child and are assumed to affect the next generation, but the behavioral effects of NN exposure at different developmental stages have not been investigated. We exposed mice to no-observed-adverse-effect level (NOAEL) doses of clothianidin (CLO) during the fetal and lactational period, and then evaluated the neurobehavioral effects in juvenile and adult mice. Significant increases in anxiety-like behavior and locomotor activity were observed in juveniles and adults, respectively, and neuronal activity and neurogenesis in the hippocampal dentate gyrus were affected in both stages. These results suggest that fetal and lactational exposure to CLO may inhibit neurogenesis and cause different behavioral abnormalities at different developmental stages. |
| Databáze: | OpenAIRE |
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