Ethanol Lock Efficacy and Associated Complications in Children With Intestinal Failure
| Autor: | Misty Troutt, Samuel A. Kocoshis, Kim Klotz, Ethan A. Mezoff, Conrad R. Cole, Lin Fei |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Catheterization Central Venous Adolescent medicine.medical_treatment Perforation (oil well) Medicine (miscellaneous) Bacteremia Article 03 medical and health sciences Young Adult 0302 clinical medicine Intestinal failure Medicine Central Venous Catheters Humans Young adult Child 030109 nutrition & dietetics Nutrition and Dietetics Ethanol business.industry Infant medicine.disease Surgery Klebsiella Infections Catheter Intestinal Diseases Klebsiella pneumoniae Catheter-Related Infections Child Preschool Cohort 030211 gastroenterology & hepatology Female business Complication Central venous catheter |
| Zdroj: | JPEN. Journal of parenteral and enteral nutrition. 40(6) |
| ISSN: | 1941-2444 |
| Popis: | Prophylactic ethanol lock therapy (ELT) reduces central line-associated bloodstream infections (CLA-BSIs) in children with intestinal failure (IF). However, the risk of associated complications is unclear. We aim to describe our experience with prophylactic ethanol locks in a cohort of patients with IF.Thirty patients on ELT from 2010-2013 were identified by review of our intestinal rehabilitation registry. Patient demographics, CLA-BSI events, and line complications were extracted. Comparisons in infection and complication rates when on and off ELT were made using a Poisson mixed-effect regression model.CLA-BSIs when on and off ELT were 3.1 and 5.5 per 1000 catheter days, respectively (P015). Overall complication rates were similar in both groups. In those patients who experienced a complication, the complication rates on ELT compared with time off ELT were significantly lower (P003). Line perforation or breakage rates declined significantly when on ELT, from 1.8 to 1.53 per 1000 catheter days (P006). Line occlusion rates also decreased on ELT, from 0.6 to 0.3 per 1000 catheter days (P =056). Infecting organisms were not different on and off ELT, and patients experienced a similar number of polymicrobial infections on or off therapy. Klebsiella pneumoniae was the most common infecting organism in both groups.Ethanol lock therapy use reduces both CLA-BSI and central line complication rates in children with IF. These results underscore the safety and efficacy of ELT use in this population. |
| Databáze: | OpenAIRE |
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