Lactobacilli modulated AMPK activity and prevented telomere shortening in ageing rats
| Autor: | Lee-Ching Lew, Amy-Sie-Yik Lau, Jia-Sin Ong, Yan-Yan Hor, Li-Oon Chuah, M.H. Jaafar, Min-Tze Liong, Kien-Pong Yap, Ghows Azzam, Azali Azlan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) medicine.medical_specialty Lactobacillus fermentum Gene Expression AMP-Activated Protein Kinases Diet High-Fat Microbiology law.invention Rats Sprague-Dawley 03 medical and health sciences Probiotic 0302 clinical medicine In vivo law Internal medicine Lactobacillus medicine Animals Telomere Shortening biology Chemistry Probiotics Galactose AMPK Aging Premature biology.organism_classification Rats Lactobacillus reuteri Disease Models Animal 030104 developmental biology Endocrinology Ageing 030220 oncology & carcinogenesis Physical Endurance Lipid Peroxidation Lactobacillus plantarum |
| Zdroj: | Beneficial Microbes. 10:883-892 |
| ISSN: | 1876-2891 1876-2883 |
| DOI: | 10.3920/bm2019.0058 |
| Popis: | This study aimed to evaluate the anti-ageing effects of different strains of lactobacilli putative probiotics on an ageing rat model as induced by D-galactose and a high fat diet. Male Sprague-Dawley rats were fed with high fat diet (54% kcal fat) and injected with D-galactose daily for 12 weeks to induce ageing. The effects of putative probiotic strains on age-related impairment such as telomere length, plasma lipid peroxidation, hepatic 5’adenosine monophosphate-activated protein kinase (AMPK) expression, as well as endurance performance were evaluated. Administration of statin, Lactobacillus plantarum DR7 (LP-DR7), Lactobacillus fermentum DR9 (LF-DR9), and Lactobacillus reuteri 8513d (LR-8513d) significantly reduced the shortening of telomere and increased the expression of AMPK subunit-α1 (P |
| Databáze: | OpenAIRE |
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