Using Web-Based Questionnaires to Assess Medication Use During Pregnancy: A Validation Study in 2 Prospectively Enrolled Cohorts
| Autor: | Nel Roeleveld, Bernke te Winkel, Eugène van Puijenbroek, Marleen M.H.J. van Gelder, Saskia Vorstenbosch |
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| Přispěvatelé: | PharmacoTherapy, -Epidemiology and -Economics, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET) |
| Rok vydání: | 2018 |
| Předmět: |
Time Factors
Epidemiology NETHERLANDS 0302 clinical medicine DESIGN Pregnancy Surveys and Questionnaires Prospective Studies Registries 030212 general & internal medicine Prospective cohort study Analgesics Medication use 030219 obstetrics & reproductive medicine MOTHERS Prenatal Care Research Design AGREEMENT Infant development Female medicine.drug Adult medicine.medical_specialty Validation study Analgesic MATERNAL RECALL Histamine Antagonists Nonprescription Drugs DRUG-USE Drug Prescriptions Sensitivity and Specificity Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] BIRTH CHARACTERISTICS Young Adult 03 medical and health sciences DELIVERY All institutes and research themes of the Radboud University Medical Center Internal medicine medicine Journal Article Humans EXPOSURE RECORDS Acetaminophen business.industry Reproducibility of Results medicine.disease Confidence interval Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] business |
| Zdroj: | American Journal of Epidemiology, 187(2), 326-336. Oxford University Press American Journal of Epidemiology, 187, 2, pp. 326-336 American Journal of Epidemiology, 187, 326-336 |
| ISSN: | 0002-9262 |
| Popis: | Medication use is often underreported in paper-based questionnaires or interviews. Web-based questionnaires may improve recall of medication use, but data on their validity are currently lacking. Participants in the Pregnancy and Infant Development (PRIDE) Study (2014-2016; n = 557) and the Pregnancy Drug Registry (pREGnant) (2015-2016; n = 169) completed a 6-week paper-based medication diary during gestational weeks 19-24 or 26-31. In week 34, they completed a Web-based questionnaire with questions on medication names, time period and frequency of use, and quantity taken. To assess the degree of underreporting, we calculated the questionnaire's sensitivity using the medication diary as the reference standard. Sensitivity was high for many medication groups, including antiepileptic medication (sensitivity (Sn) = 0.96, 95% confidence interval (CI): 0.89, 1.00), antacids (Sn = 0.89, 95% CI: 0.86, 0.93), and iron preparations (Sn = 0.81, 95% CI: 0.64, 0.98). However, medications for short-term use were underreported more frequently, with sensitivities of 0.54 (95% CI: 0.35, 0.72) for antihistamines, 0.63 (95% CI: 0.57, 0.69) for analgesic and antipyretic agents, and 0.57 (95% CI: 0.51, 0.64) for acetaminophen. Shortening the period of time between exposure and questionnaire administration increased sensitivity substantially. In conclusion, underreporting in Web-based questionnaires is limited for many medication groups. In prospective studies, underreporting of medications for short-term use may be reduced by decreasing the interval between consecutive questionnaires. |
| Databáze: | OpenAIRE |
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