Effect of Intensive Insulin Therapy on the Somatotropic Axis of Critically Ill Children
| Autor: | Erik Van Herck, Michael P. Brugts, Greet Van den Berghe, Dieter Mesotten, Robert C. Baxter, Steven W. J. Lamberts, Ilse Vanhorebeek, Marijke Gielen, Willy Coopmans, Joop A. M. J. L. Janssen |
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| Přispěvatelé: | Internal Medicine |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Hydrocortisone Critical Illness Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Context (language use) Hypoglycemia Intensive Care Units Pediatric Biochemistry chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Hypoglycemic Agents Insulin Prospective Studies Insulin-Like Growth Factor I Child Prospective cohort study Pediatric intensive care unit C-Peptide Human Growth Hormone business.industry C-peptide Biochemistry (medical) Infant Newborn Case-control study Infant Glucagon medicine.disease Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor Binding Protein 3 chemistry Case-Control Studies Child Preschool Female business medicine.drug |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 96(8), 2558-2566. Endocrine Society |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Context: Intensive insulin therapy (IIT) improved outcome in the adult and pediatric intensive care unit (PICU) compared with conventional insulin therapy (CIT). IIT did not increase the anabolic hormone IGF-I in critically ill adults, but feeding in critically ill children and pediatric hormonal responses may differ. Twenty-five percent of the children with IIT experienced hypoglycemia, which may have evoked counterregulatory responses. Objective: We hypothesized that IIT reactivates the somatotropic axis and anabolism in PICU patients. Design: This was a preplanned subanalysis of a randomized controlled trial on IIT. Patients: We studied 369 patients who stayed in PICU for at least 3 d (study 1) and 126 patients in a nested case-control study (study 2). Main Outcome Measures: Circulating insulin, C-peptide, GH, IGF-I, bioavailable IGF-I, IGF-binding protein (IGFBP)-1, IGFBP-3, and acid-labile subunit were analyzed upon admission and d 3. In the nested case-control study, the somatotropic axis, cortisol, and glucagon were analyzed before and after hypoglycemia. Results: On d 3, C-peptide was more than 10-fold lower (P < 0.0001) in the IIT group than in the CIT group. IIT increased circulating GH (P = 0.04) and lowered bioavailable IGF-I (P = 0.002). IIT also decreased IGFBP-3 (P = 0.0005) and acid-labile subunit (P = 0.007), while increasing IGFBP-1 (P = 0.04) and the urea/creatinine ratio, a marker of catabolism (P = 0.03). In the nested case-control study, IGFBP-1 was increased after hypoglycemia, whereas the somatotropic axis and the counterregulatory hormones cortisol and glucagon did not change. Conclusions: Despite improved PICU outcome, IIT did not counteract the catabolic state of critical illness. Suppression of portal insulin may have resulted in lower bioavailable IGF-I. (J Clin Endocrinol Metab 96: 2558-2566, 2011) |
| Databáze: | OpenAIRE |
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