Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012
| Autor: | Jianguo Wu, Yingle Liu, Weijian Lai, Zhu Yang, Hongjian Li, Jin Liu, Michelle Liu, Jun Luo, Gia-Phong Vu, Phong Trang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine China medicine.medical_specialty Disease medicine.disease_cause Article Disease Outbreaks 03 medical and health sciences Age Distribution 0302 clinical medicine stomatognathic system Environmental health Epidemiology medicine Enterovirus 71 Humans 030212 general & internal medicine Child Phylogeny Multidisciplinary Base Sequence Geography biology Public health Outbreak Sequence Analysis DNA biology.organism_classification Enterovirus A Human 030104 developmental biology Child Preschool Enterovirus Female Seasons Hand Foot and Mouth Disease Sequence Alignment Foot (unit) |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep38451 |
| Popis: | Infection of enterovirus 71 (EV71) and associated hand, foot, and mouth disease (HFMD) are recognized as emerging public health issues worldwide. Hundreds of thousands of children are annually infected with EV71 and develop HFMD in China alone. Studies of EV71 infection are critical to the treatment and prevention of the associated HFMD outbreaks. In this report, we studied an outbreak of 105 HFMD cases in Shawo Township of China between September to October 2012. More than 90% of cases were children younger than 9 years old, with over 50% of cases aged 3–6 years old. Laboratory studies detected a high prevalence of EV71 and suggested EV71 as the most common enterovirus causing HFMD in Shawo. Sequencing analysis showed that the EV71 strains from Shawo belong to the C4 subgenotype, and are phylogenetically more related to those from the distant city of Nanchang than those from the nearby city of Wuhan with distinct variations. More girls were found to be associated with EV71 in Shawo whereas more boys were associated with EV71 in Wuhan and Nanchang. Our studies further the understanding of the molecular epidemiological features of HFMD and infection by enteroviruses in China. |
| Databáze: | OpenAIRE |
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