Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site

Autor: Kathrin Lang, Séverine Freisz, Eric Ennifar, Ronald Micura, Philippe Dumas
Přispěvatelé: Architecture et réactivité de l'ARN (ARN), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Institute of Organic Chemistry, Center for Molecular Biosciences, Univ
Rok vydání: 2008
Předmět:
Antibiotics
Human immunodeficiency virus (HIV)
MESH: Base Sequence
medicine.disease_cause
Virus Replication
01 natural sciences
antibiotics
MESH: HIV-1
ComputingMilieux_MISCELLANEOUS
0303 health sciences
Chemistry
RNA structures
Aminoglycoside
MESH: Aminoglycosides
General Medicine
3. Good health
Anti-Bacterial Agents
MESH: Nucleic Acid Conformation
MESH: RNA
Viral
RNA
Viral
MESH: Genome
Viral
Dimerization
drug design
Stereochemistry
medicine.drug_class
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Genome
Viral
010402 general chemistry
Catalysis
03 medical and health sciences
Molecular recognition
MESH: Anti-Bacterial Agents
medicine
Humans
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
030304 developmental biology
MESH: Humans
Base Sequence
010405 organic chemistry
MESH: Virus Replication
HIV
RNA
General Chemistry
Virology
0104 chemical sciences
Aminoglycosides
MESH: Dimerization
Duplex (building)
HIV-1
Nucleic Acid Conformation
molecular recognition
Genomic rna
Zdroj: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2008, 47 (22), pp.4110-3. ⟨10.1002/anie.200800726⟩
Angewandte Chemie (English Edition)
Angewandte Chemie (English Edition), John Wiley & Sons, 2008, 47 (22), pp.4110-3. ⟨10.1002/anie.200800726⟩
ISSN: 1521-3773
1433-7851
0570-0833
Popis: International audience
Databáze: OpenAIRE
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