Depletion of langerin + cells enhances cutaneous wound healing
| Autor: | Allison M. Tschirley, Gabriella S. Stuart, Lyn M. Wise, Merilyn Hibma, Aarthi Rajesh, Nicola C. Real, Jenny Ahn |
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| Rok vydání: | 2020 |
| Předmět: |
Langerin
Angiogenesis Immunology Mice medicine Animals Immunology and Allergy Lectins C-Type Receptor Cells Cultured Cell Proliferation Skin Mice Knockout Wound Healing integumentary system biology Chemistry Granulocyte-Macrophage Colony-Stimulating Factor Lectin Granulation tissue Original Articles Dendritic Cells Cell biology Mice Inbred C57BL Mannose-Binding Lectins Wound area medicine.anatomical_structure Langerhans Cells Antigens Surface Granulation Tissue biology.protein Angiogenesis Inducing Agents Female Cutaneous wound Wound healing |
| Zdroj: | Immunology |
| ISSN: | 1365-2567 0019-2805 |
| Popis: | Langerin is a C‐type lectin receptor that is expressed on Langerhans cells and langerin‐positive dermal dendritic cells in the skin. Little is known about the function of langerin(+) cells in wound healing. In this study, the effects of ablation of langerin(+) cells on healing of a full‐thickness excision wound were investigated using the langerin‐DTR depletable mouse. Strikingly, depletion of langerin(+) cells resulted in more rapid reduction in wound area. Accelerated wound healing in the langerin(+)‐cell‐depleted group was characterized by enhanced neo‐epidermis and granulation tissue formation, and increased cellular proliferation within the newly formed tissues. Accelerated healing in the absence of langerin(+) cells was associated with increased levels of granulocyte–macrophage colony‐stimulating factor, F4/80(+) cells and blood vessels within the granulation tissue. These data support an inhibitory role for langerin(+) cells during wound healing. Therapies that suppress langerin(+) cells or their function may therefore have utility in progressing the healing of wounds in humans. |
| Databáze: | OpenAIRE |
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