Structures and functions of penta-EF-hand calcium-binding proteins and their interacting partners: enigmatic relationships between ALG-2 and calpain-7
| Autor: | Masatoshi Maki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Protein family Endosome penta-EF-hand Applied Microbiology and Biotechnology Biochemistry ESCRT Analytical Chemistry Structure-Activity Relationship 03 medical and health sciences 0302 clinical medicine Calcium-binding protein Humans Molecular Biology Endosomal Sorting Complexes Required for Transport biology Chemistry EF hand Calcium-Binding Proteins Organic Chemistry Calpain protease General Medicine Biological Evolution Cell biology Enzyme Activation Vesicular transport protein Protein Transport 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Signal transduction Apoptosis Regulatory Proteins calpain Protein Binding Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 84(4):651-660 |
| ISSN: | 0916-8451 |
| Popis: | The penta-EF-hand (PEF) protein family includes ALG-2 (gene name, PDCD6) and its paralogs as well as classical calpain family members. ALG-2 is a prototypic PEF protein that is widely distributed in eukaryotes and interacts with a variety of proteins in a Ca2+-dependent manner. Mammalian ALG-2 and its interacting partners have various modulatory roles including roles in cell death, signal transduction, membrane repair, ER-to-Golgi vesicular transport, and RNA processing. Some ALG-2-interacting proteins are key factors that function in the endosomal sorting complex required for transport (ESCRT) system. On the other hand, mammalian calpain-7 (CAPN7) lacks the PEF domain but contains two microtubule-interacting and trafficking (MIT) domains in tandem. CAPN7 interacts with a subset of ESCRT-III proteins through the MIT domains and regulates EGF receptor downregulation. Structures and functions of ALG-2 and those of its interacting partners as well as relationships with the calpain family are reviewed in this article. Published online: 09 Dec 2019 ファイル公開：2020/12/09 |
| Databáze: | OpenAIRE |
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