Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure

Autor: Anna Bergström, Nathanaël Lemonnier, Marie Standl, Inger Kull, Aitana Lertxundi, Simon Kebede Merid, Joachim Heinrich, Josep M. Antó, Jordi Sunyer, Olena Gruzieva, Jean Bousquet, Åsa M. Wheelock, Erik Melén, Gerard H. Koppelman, Mariona Bustamante, Daniel Aguilar, Loreto Santa-Marina
Přispěvatelé: European Commission, Groningen Research Institute for Asthma and COPD (GRIAC), Michel-Avella, Amandine, Karolinska Institutet [Stockholm], Universitat Pompeu Fabra [Barcelona] (UPF), Helmholtz Zentrum München = German Research Center for Environmental Health, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Ludwig Maximilian University [Munich] (LMU), University of Melbourne, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Instituto de Salud Carlos III [Madrid] (ISC), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], CIBER de Epidemiología y Salud Pública (CIBERESP), University of Groningen [Groningen]
Jazyk: angličtina
Rok vydání: 2021
Předmět:
air-pollution exposure
microrna-1296
MESH: Air Pollution
010504 meteorology & atmospheric sciences
MESH: Air Pollutants
proliferation
MESH: Environmental Exposure
air pollution
MESH: Epigenomics
integration
010501 environmental sciences
Biology
01 natural sciences
Transcriptome
MESH: DNA Methylation
children
Adverse health effect
childhood asthma
MESH: Child
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Genomics [q-bio.GN]
Gene expression
[SDV.EE.SANT] Life Sciences [q-bio]/Ecology
environment/Health
lcsh:Environmental sciences
0105 earth and related environmental sciences
General Environmental Science
Genetic association
Genetics
MESH: Adolescent
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology
environment/Health
lcsh:GE1-350
profile
MESH: Humans
DNA methylation
association
cohort
invasion
3. Good health
MESH: Particulate Matter
gene expression
[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry
Molecular Biology/Genomics [q-bio.GN]
Air Pollution
Children
Dna Methylation
Gene Expression
Integration
adolescence
metaanalysis
Zdroj: Addi. Archivo Digital para la Docencia y la Investigación
instname
Environ. Int. 146:106248 (2021)
Environment International, Vol 146, Iss, Pp 106248-(2021)
Environment international, 146:106248. PERGAMON-ELSEVIER SCIENCE LTD
Environment International
Environment International, 2021, 146, pp.106248. ⟨10.1016/j.envint.2020.106248⟩
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
ISSN: 2017-0114
0160-4120
Popis: Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this meta-analysis of transcriptome-wide association studies of 656 children and adolescents from three European cohorts participating in the MeDALL Consortium, we found two differentially expressed transcript clusters (FDR p < 0.05) associated with exposure to particulate matter < 2.5 mu m in diameter (PM2.5) at birth, one of them mapping to the MIR1296 gene. Further, by integrating gene expression with DNA methylation using Functional Epigenetic Modules algorithms, we identified 9 and 6 modules in relation to PM2.5 exposure at birth and at current address, respectively (including NR1I2, MAPK6, TAF8 and SCARA3). In conclusion, PM2.5 exposure at birth was linked to differential gene expression in children and adolescents. Importantly, we identified several significant interactome hotspots of gene modules of relevance for complex diseases in relation to PM2.5 exposure. The research leading to these results has received funding from the European Community's Seventh Framework Program under grant agreement numbers: 211,250 (ESCAPE), and 261,357 (MeDALL), and the European Research Council (grant agreement number 757919, TRIBAL). NL was recipient of ANR-15-IDEX-02 grant. BAMSE: BAMSE was supported by The Swedish Research Council, The Swedish Heart-Lung Foundation, Region Stockholm, the Strategic Research Programme (SFO) in Epidemiology at Karolinska Institutet, The Swedish Research Council Formas and the Swedish Environment Protection Agency, the Swedish Asthma and Allergy Research Foundation, the Cancer and Allergy Foundation. O. Gruzieva is supported by the Swedish Research Council for Health, Working life and Welfare (FORTE 2017-01146). GINIplus: The GINIplus study was mainly supported for the first 3 years of the Federal Ministry for Education, Science, Research and Technology (interventional arm) and Helmholtz Zentrum Munich (former GSF) (observational arm). The 4 year, 6 year, 10 year and 15 year follow-up examinations of the GINIplus study were covered from the respective budgets of the 5 study centres (Helmholtz Zentrum Munich (former GSF), Research Institute at Marien-Hospital Wesel, LMU Munich, TU Munich and from 6 years onwards also from IUF -Leibniz Research-Institute for Environmental Medicine at the University of Dusseldorf) and a grant from the Federal Ministry for Environment (IUF Dusseldorf, FKZ 20462296). Further, the 15-year follow-up examination of the GINIplus study was supported by the Commission of the European Communities, the 7th Framework Program: MeDALL project, and as well by the companies Mead Johnson and Nestle. INMA: INMA project was mainly supported by the Commission of the European Community, the 7th Framework Program: MeDALL project and by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI04/1436; PI06/0867; PI08/1151; and PI18/01142 incl. FEDER funds), and Generalitat de Catalunya-CIRIT 1999SGR 00241, Department of Health of the Basque Government (2005111093), Provincial Government of Gipuzkoa (DFG06/002), and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain)
Databáze: OpenAIRE
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