| Autor: |
Clinton D. Bahler, Mark A. Green, Mark A. Tann, Jordan K. Swensson, Katrina Collins, David Alexoff, Hank Kung, Eric Brocken, Carla J. Mathias, Liang Cheng, Gary D. Hutchins, Michael O. Koch |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Urologic oncology. 41(1) |
| ISSN: |
1873-2496 |
| Popis: |
Incontinence and impotence occur following radical prostatectomy due to injury to nerves and sphincter muscle. Preserving nerves and muscle adjacent to prostate cancer risks positive surgical margins. Advanced imaging with MRI has improved cancer localization but limitations exist.To measure the accuracy for assessing extra-prostatic extension at nerve bundles for 2 PSMA-PET tracers and to compare the PET accuracy to standard-of-care predictors including MRI and biopsy results.We studied men with PSMA-targeted PET imaging, performed prior to prostatectomy in men largely with intermediate to high-risk prostate cancer, and retrospectively evaluated for assessment of extra-prostatic extension with whole-mount analysis as reference standard. Two different PSMA-PET tracers were included:Pre-operative PSMA-PET imaging was available for 71 patients with eitherPresurgical PSMA-PET appeared useful as a tool for surgical planning, changing treatment plans in men with ≥4+3 or multi-core 3+4 prostate cancer resulting in preservation of nerve-bundles. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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