Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
| Autor: | Kendra V. Johnson, Crystal Koralis Colón Ortiz, Carol M. Troy, Claire W. Chen, Ying Y. Jean, Stephanie K. Yuen, Maria Avrutsky, Jacqueline Lawson, Elisa Canepa, Alexandra J. White, Anna Michelle Potenski, Fatima N. Morales, Guy S. Salvesen, Scott J. Snipas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cell death
Male Pathology medicine.medical_specialty Cell biology Retinal Vein Neurovascular injury Science General Physics and Astronomy Pathogenesis General Biochemistry Genetics and Molecular Biology Retina Endothelial activation Mice Text mining Ischemia Occlusion Blood-Retinal Barrier Retinal Vein Occlusion Medicine Animals Genetic Predisposition to Disease lcsh:Science Author Correction Hypoxia Caspase-9 Caspase 7 Inflammation Mice Knockout Multidisciplinary biology business.industry Endothelial Cells General Chemistry Vascular System Injuries Caspase 9 Mice Inbred C57BL Disease Models Animal Mechanisms of disease biology.protein lcsh:Q Female Rabbits business Neuroscience |
| Zdroj: | Nature Communications Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020) |
| ISSN: | 2041-1723 |
| Popis: | Central nervous system ischemic injury features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here we show that activation of endothelial caspase-9 after hypoxia-ischemia is a critical event in subsequent dysfunction of the blood-retina barrier, using a panel of interrelated ophthalmic in vivo imaging measures in a mouse model of retinal vein occlusion (RVO). Rapid nonapoptotic activation of caspase-9 and its downstream effector caspase-7 in endothelial cells promotes capillary ischemia and retinal neurodegeneration. Topical eye-drop delivery of a highly selective caspase-9 inhibitor provides morphological and functional retinal protection. Inducible endothelial-specific caspase-9 deletion phenocopies this protection, with attenuated retinal edema, reduced inflammation and preserved neuroretinal morphology and function following RVO. These results reveal a non-apoptotic function of endothelial caspase-9 which regulates blood-retina barrier integrity and neuronal survival, and identify caspase-9 as a therapeutic target in neurovascular disease. |
| Databáze: | OpenAIRE |
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