Effects of specific dosages of magnesium and zinc on the teratogenicity of cadmium, nickel, and cobalt in Xenopus embryos, as assessed by the FETAX test
| Autor: | Seref Erdogan, Yasar Sertdemir, Ayper Boga |
|---|---|
| Přispěvatelé: | Çukurova Üniversitesi |
| Rok vydání: | 2008 |
| Předmět: |
inorganic chemicals
animal structures Xenopus Health Toxicology and Mutagenesis chemistry.chemical_element Metal Interaction Zinc Toxicology Magnesium (Mg2+) Divalent Metal TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY chemistry.chemical_classification Cadmium Chemical Health and Safety biology Zinc (Zn 2+)) Magnesium lcsh:RM1-950 Public Health Environmental and Occupational Health FETAX Articles biology.organism_classification lcsh:Therapeutics. Pharmacology chemistry visual_art Toxicity embryonic structures visual_art.visual_art_medium Cobalt Nuclear chemistry |
| Zdroj: | Dose-Response, Vol 6 (2008) |
| ISSN: | 1559-3258 |
| Popis: | The objective of this study was to determine if exposure to divalent cations, Cd2+, Ni2+, and Co2+ would lead to malformations in Xenopus laevis embryos, and whether addition of Mg2+ and Zn2+; separately and in combination, would reduce their toxicity and teratogenicity on the embryos of Xenopus laevis as assessed by 96-h FETAX tests. Results indicate that exposure to Cd2+, Ni2+ or Co2+ lead to an increase in toxicity and teratogenicity in embryos, whereas Mg2+, Zn2+, or a combination of them reduced the toxic and teratogenic effects of these divalent cations. Modulation of Cd2+, Ni2+ or Co2+ toxicity and teratogenicity by Mg2+ and Zn2+, varied with the metal. Zn2+ was observed to be a better suppressor of Co2+ toxicity and teratogenicity than Mg2+. In contrast, Ni2+, and Cd2+ teratogenicity was reduced more prominently by Mg2+. On the other hand, combination of Mg2+ and Zn2+ showed potentialization effect on all divalent cation toxicity and teratogenicity. We concluded that Mg2+ and Zn2+ reduced the toxicity and teratogenicity of Cd2+, Ni2+, Co2+. |
| Databáze: | OpenAIRE |
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