Variations in Magnesium Concentration Are Associated with Increased Mortality: Study in an Unselected Population of Hospitalized Patients

Autor: Milena Małecka, Olga Ciepiela, Justyna Malinowska
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
Adolescent
Hospitalized patients
cut-off value
chemistry.chemical_element
lcsh:TX341-641
030204 cardiovascular system & hematology
serum magnesium
Gastroenterology
Article
Hypomagnesemia
Young Adult
hypomagnesemia
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Magnesium
In patient
Hospital Mortality
030212 general & internal medicine
Aged
Retrospective Studies
Aged
80 and over
Inpatients
Nutrition and Dietetics
business.industry
cut-off value
hypomagnesemia
hospitalization
mortality
serum magnesium
Magnesium level
Middle Aged
medicine.disease
mortality
Increased risk
chemistry
Unselected population
Female
Poland
Hypermagnesemia
business
lcsh:Nutrition. Foods and food supply
Magnesium Deficiency
hospitalization
Food Science
Zdroj: Nutrients
Volume 12
Issue 6
Nutrients, Vol 12, Iss 1836, p 1836 (2020)
ISSN: 2072-6643
DOI: 10.3390/nu12061836
Popis: Dysmagnesemia is a serious disturbance of microelement homeostasis. The aim of this study was to analyze the distribution of serum magnesium concentrations in hospitalized patients according to gender, age, and result of hospitalization. The study was conducted from February 2018 to January 2019 at the Central Clinical Hospital in Warsaw. Laboratory test results from 20,438 patients were included in this retrospective analysis. When a lower reference value 0.65 mmol/L was applied, hypermagnesemia occurred in 196 patients (1%), hypomagnesemia in 1505 patients (7%), and normomagnesemia in 18,711 patients (92%). At a lower reference value of 0.75 mmol/L, hypomagnesemia was found in 25% and normomagnesemia in 74% of patients. At a lower reference value of 0.85 mmol/L, hypomagnesemia was found in 60% and normomagnesemia in 39% of patients. Either hypo- or hyper-magnesemia was associated with increased risk of in-hospital mortality. This risk is the highest in patients with hypermagnesemia (40.1% of deaths), but also increases inversely with magnesium concentration below 0.85 mmol/L. Serum magnesium concentration was not gender-dependent, and there was a slight positive correlation with age (p <
0.0001, r = 0.07). Large fluctuations in serum magnesium level were associated with increased mortality (p = 0.0017). The results indicate that dysmagnesemia is associated with severe diseases and generally severe conditions. To avoid misdiagnosis, an increase of a lower cut-off for serum magnesium concentration to at least 0.75 mmol/L is suggested.
Databáze: OpenAIRE
Externí odkaz: