Polyglycerol Ester-Based Low Energy Nanoemulsions with Red Raspberry Seed Oil and Fruit Extracts: Formulation Development toward Effective In Vitro/In Vivo Bioperformance
| Autor: | Slobodanka Tamburic, Aleksandra Janosevic Lezaic, Jelena Antić-Stanković, Danijela Randjelovic, Ana Gledović, Ines Nikolić, Marija Tasic-Kostov, Veljko Krstonošić, Dragana Bozic, Dusan Ilic, Snezana Savic |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
MTT
Antioxidant DPPH General Chemical Engineering medicine.medical_treatment nanoemulsion biocompatible antioxidant activity 02 engineering and technology 01 natural sciences Article lcsh:Chemistry chemistry.chemical_compound Differential scanning calorimetry phase inversion composition (PIC) In vivo polyglycerol ester medicine Polyglyc-erol ester General Materials Science Microemulsion skin hydration red raspberry seed oil Chromatography 010405 organic chemistry French oak fruit extract 021001 nanoscience & nanotechnology 0104 chemical sciences Blowing a raspberry low energy HaCaT chemistry lcsh:QD1-999 0210 nano-technology Phase inversion |
| Zdroj: | Nanomaterials Nanomaterials, Vol 11, Iss 217, p 217 (2021) Volume 11 Issue 1 |
| ISSN: | 2079-4991 |
| Popis: | This study focuses on the development of biocompatible oil-in-water (O/W) nanoemulsions based on polyglycerol esters, as promising carriers for natural actives: red raspberry seed oil&mdash RO and hydro-glycolic fruit extracts from red raspberry&mdash RE and French oak&mdash FE. Nanoemulsions were obtained via phase inversion composition (PIC) method at room temperature by dilution of microemulsion phase, confirmed by visual appearance, percentage of transmittance, microscopic, rheological and Differential Scanning Calorimetry (DSC) investigations. The results have shown that the basic RO-loaded formulation could be further enriched with hydro-glycolic fruit extracts from red raspberry or French oak, while keeping a semi-transparent appearance due to the fine droplet size (Z-ave: 50 to 70 nm, PDI value &le 0.1). The highest antioxidant activity (~92% inhibition of the DPPH radical) was achieved in the formulation containing both lipophilic (RO) and hydrophilic antioxidants (FE), due to their synergistic effect. The nanoemulsion carrier significantly increased the selective cytotoxic effect of RO towards malignant melanoma (Fem-X) cells, compared to normal human keratinocytes (HaCaT). In vivo study on human volunteers showed satisfactory safety profiles and significant improvement in skin hydration during 2 h after application for all nanoemulsions. Therefore, polyglycerol ester-based nanoemulsions can be promoted as effective carriers for red raspberry seed oil and/or hydro-glycolic fruit extracts in topical formulations intended for skin protection and hydration. |
| Databáze: | OpenAIRE |
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