Olanzapine Increases Neural Chemorepulsant—Draxin Expression in the Adult Rat Hippocampus
| Autor: | Marek Krzystanek, Jakub Skałbania, John J. Worthington, Katarzyna Bogus, Artur Pałasz, Jacek Francikowski, Aleksandra Suszka-Świtek, Inga Mrzyk |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
draxin
medicine.drug_class hippocampus olanzapine Pharmaceutical Science Hippocampus Atypical antipsychotic lcsh:Medicine lcsh:RS1-441 Context (language use) Hippocampal formation Biology Subgranular zone lcsh:Pharmacy and materia medica 03 medical and health sciences Paracrine signalling 0302 clinical medicine Drug Discovery medicine 030304 developmental biology 0303 health sciences Communication Dentate gyrus Neurogenesis lcsh:R adult neurogenesis medicine.anatomical_structure Molecular Medicine Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Pharmaceuticals, Vol 14, Iss 298, p 298 (2021) Pharmaceuticals |
| ISSN: | 1424-8247 |
| Popis: | Draxin belongs to the family of inhibitory axon-guiding factors that regulate neuronal migration and axonal spreading in the developing brain. This glycoprotein has recently been considered to play an important role both in hippocampal differentiation and adult neurogenesis in the dentate gyrus. Given that it has been reported that antipsychotic drugs may affect neurite growth and neurogenesis, we have therefore investigated whether chronic treatment with olanzapine modulates draxin immunoreactivity in the adult rat hippocampus. After analysis of local fluorescence intensity, we found a significant increase of draxin immunoexpression both in the subgranular zone (SGZ) and granular zone of the rat hippocampus following long-term olanzapine administration. This study reveals, for the first time, the modulatory effect of the atypical antipsychotic medication olanzapine on expression of the novel chemorepulsive protein draxin in the context of adult neurogenesis regulation. Moreover, this is the first report dealing with pharmacological aspects of draxin signaling. An elevated draxin expression may indirectly support a recently formulated hypothesis that olanzapine may drive adult neurogenesis via paracrine draxin-related signaling. This action of draxin is a new element in the neurogenesis mechanism that may be part of the action of second-generation antipsychotics in the treatment of schizophrenia, indicating more detailed molecular studies are urgently required to fully investigate these potential novel mechanisms of neurogenesis. |
| Databáze: | OpenAIRE |
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