Inhibition enhances memory capacity: optimal feedback, transient replay and oscillations
| Autor: | Álvaro Tejero-Cantero, Axel Kammerer, Christian Leibold |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Feedback
Physiological Neurons Cognitive Neuroscience Models Neurological Hippocampus Action Potentials Neural Inhibition Neurophysiology Hippocampal formation Content-addressable memory Sensory Systems Cellular and Molecular Neuroscience Nonlinear Dynamics Biological Clocks Memory Biological neural network Premovement neuronal activity Animals Humans Transient (computer programming) Psychology Neuroscience Episodic memory |
| Zdroj: | Journal of computational neuroscience. 34(1) |
| ISSN: | 1573-6873 |
| Popis: | Recurring sequences of neuronal activation in the hippocampus are a candidate for a neurophysiological correlate of episodic memory. Here, we discuss a mean-field theory for such spike sequences in phase space and show how they become unstable when the neuronal network operates at maximum memory capacity. We find that inhibitory feedback rescues replay of the sequences, giving rise to oscillations and thereby enhancing the network's capacity. We further argue that transient sequences in an overloaded network with feedback inhibition may provide a mechanistic picture of memory-related neuronal activity during hippocampal sharp-wave ripple complexes. |
| Databáze: | OpenAIRE |
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