PEP-19 overexpression in human uterine leiomyoma
| Autor: | Mitsunaga Konishi, Ken Fukuhara, Takashi Kusakari, Hiroaki Shime, Kanako Nanbu, Jun Fujita, Ayako Suzuki, Noriomi Matsumura, Masatoshi Kariya, Shingo Fujii, Kenji Takakura, Haruhiko Yagi, Takanobu Kanamori, Masaki Mandai, Chika Momma |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Leiomyosarcoma Embryology medicine.medical_specialty Candidate gene education Uterus Nerve Tissue Proteins Biology Pathogenesis Cell Line Tumor Internal medicine Genetics medicine Humans RNA Messenger Molecular Biology Oligonucleotide Array Sequence Analysis Microscopy Confocal Uterine leiomyoma Leiomyoma Microarray analysis techniques Myometrium Obstetrics and Gynecology Cell Biology Middle Aged Blotting Northern musculoskeletal system medicine.disease Immunohistochemistry female genital diseases and pregnancy complications Up-Regulation medicine.anatomical_structure Endocrinology Reproductive Medicine Uterine Neoplasms cardiovascular system Cancer research Female circulatory and respiratory physiology Developmental Biology |
| Zdroj: | Molecular Human Reproduction. 9:709-717 |
| ISSN: | 1460-2407 |
| DOI: | 10.1093/molehr/gag088 |
| Popis: | Although uterine leiomyomas represent one of the most common neoplasms in adult women, their pathogenesis remains poorly understood. A cDNA microarray analysis was performed to search for candidate genes expressed to a greater degree in leiomyoma compared with matched myometrium. A total of 15 candidate genes was obtained; neuron-specific protein PEP-19 (Purkinje cell protein 4; PCP 4) exhibited a striking difference in expression between leiomyoma and myometrium. Although PEP-19 expression has been reported exclusively in the central nervous system, the present study demonstrated that PEP-19 is also expressed in other human organs, including prostate, kidney and uterus. To clarify the role of PEP-19 in the pathogenesis of leiomyomas, PEP-19 expression was investigated for a series of human leiomyoma, as well as normal myometrium and leiomyosarcoma. PEP-19 mRNA and protein expression were much stronger in leiomyomas compared with normal myometrium, suggesting that PEP-19 might be involved in leiomyoma pathogenesis. |
| Databáze: | OpenAIRE |
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