The Thyroid and the Kidney: A Complex Interplay in Health and Disease
| Autor: | Konstantina Trigka, Periklis Dousdampanis, Costas Fourtounas, Georgios A. Vagenakis |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Thyroid Hormones
endocrine system medicine.medical_specialty endocrine system diseases Biomedical Engineering Medicine (miscellaneous) Renal function Bioengineering Disease urologic and male genital diseases Bioinformatics Renin-Angiotensin System Biomaterials Internal medicine medicine Humans Kidney urogenital system business.industry Thyroid General Medicine Thyroid Diseases Endocrinology medicine.anatomical_structure Creatinine Thyroid hormones Kidney Diseases business Biomarkers Glomerular Filtration Rate |
| Zdroj: | The International Journal of Artificial Organs. 37:1-12 |
| ISSN: | 1724-6040 0391-3988 |
| DOI: | 10.5301/ijao.5000300 |
| Popis: | Thyroid hormones may directly affect the kidney and altered kidney function may also contribute to thyroid disorders. The renal manifestations of thyroid disorders are based on hemodynamic alterations or/and to direct effects of thyroid hormones. The renin-angiotensin system plays a crucial role in the cross-talk between the thyroid and the kidney. Hypothyroidism may be accompanied by an increase of serum creatinine and reduction of glomerular filtration rate (GFR), whereas hyperthyroidism may increase GFR. Treatment of thyroid disorders may lead to normalization of GFR. Primary and subclinical hypothyroidism and low triiodothyronine (T3) syndrome are common features in patients with chronic kidney disease (CKD). In addition low levels of thyroid hormones may predict a higher risk of cardiovascular and overall mortality in patients with end-stage renal disease. The causal nature of this correlation remains uncertain. In this review, special emphasis is given to the thyroid pathophysiology, its impact on kidney function and CKD and the interpretation of laboratorial findings of thyroid dysfunction in CKD. |
| Databáze: | OpenAIRE |
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