Scavenger receptor class B type 1 gene rs5888 single nucleotide polymorphism and the risk of coronary artery disease and ischemic stroke: a case-control study
| Autor: | Xiao-Na Zeng, Wei Wang, Dong-Feng Wu, Lynn Htet Htet Aung, Ping Huang, Wu-Xian Chen, Jian Wu, Ke-Ke Huang, Rui-Xing Yin, Xiao-Li Cao |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Apolipoprotein B Genotype Single-nucleotide polymorphism Coronary Artery Disease Bioinformatics Gastroenterology Polymorphism Single Nucleotide Coronary artery disease Internal medicine medicine SNP Humans Scavenger receptor class B type 1 gene Genotyping Genetic Association Studies Aged Ischemic stroke biology Case-control study General Medicine Middle Aged Scavenger Receptors Class B Lipid medicine.disease Lipids SCARB1 Single nucleotide polymorphism Stroke Case-Control Studies biology.protein Female Polymorphism Restriction Fragment Length Research Paper |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| Popis: | Background: Our previous studies have showed that the rs5888 single nucleotide polymorphism (SNP) in Scavenger receptor class B type 1 (SCARB1) gene is associated with serum lipid levels in the general Chinese populations. The present study was undertaken to detect the associations between rs5888 SNP and the risk of coronary artery disease (CAD) and ischemic stroke (IS). Methods: A total of 1,716 unrelated subjects (CAD, 601; IS, 533; and healthy controls, 582) were included in this study. Genotyping of the rs5888 SNP were determined by polymerase chain reaction and restriction fragment length polymorphism. Results: The genotypic frequencies of SCARB1 rs5888 SNP were different between CAD patients and controls, the subjects with TT genotype had high risk of CAD (OR = 1.76, P = 0.038 for TT vs. CC; and OR = 1.75, P = 0.036 for TT vs. CC/CT). There was no significant association between genotypes and the risk of IS. Further analysis showed that the subjects with TT genotype in the total population had lower levels of high-density lipoprotein cholesterol than the subjects with CC/CT genotypes (P < 0.05), the subjects with TT genotype in controls but not in CAD or IS patients had higher levels of serum LDL-C and ApoB than those with CC genotype (P < 0.05 for each). Conclusions: The present study suggests that the SCARB1 rs5888 SNP influences serum lipid levels, and is associated with the risk of CAD. |
| Databáze: | OpenAIRE |
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