Near Fatal Asthma: Clinical and Airway Biopsy Characteristics
| Autor: | Elton Katagihara, Ilias C. Papanikolaou, Richard G. Barbers, Om P. Sharma, Ashish Patel, Michael Koss, Maggie Arenas, Khalid Chan, Colleen G. Azen |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
lcsh:RC705-779
Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Exacerbation Article Subject business.industry medicine.medical_treatment lcsh:Diseases of the respiratory system General Medicine medicine.disease Gastroenterology Pathophysiology Internal medicine Eosinophilic medicine Eosinophilia Intubation Leukocytosis medicine.symptom Airway business Asthma Research Article |
| Zdroj: | Pulmonary Medicine Pulmonary Medicine, Vol 2012 (2012) |
| ISSN: | 2090-1844 2090-1836 |
| Popis: | Background. Inflammation and remodeling are integral parts of asthma pathophysiology. We sought to describe the clinical and pathologic features of near fatal asthma exacerbation (NFE). Methods. Bronchial biopsies were collected prospectively from NFE I subjects. Another NFE II group and a moderate severity exacerbation control group (ME II) were retrospectively identified—no biopsies obtained. Results. All NFE II ( 𝑛 = 9 ) subjects exhibited remodeling and significant inflammation (eosinophilic, neutrophilic). NFE II group ( 𝑛 = 3 7 ) had a significant history of prior intubation and inhaled corticosteroids usage compared to ME II group ( 𝑛 = 4 1 ). They also exhibited leukocytosis, eosinophilia, and longer hospitalization days. Conclusions. Remodeling, eosinophilic, and neutrophilic inflammation were observed in NFE. NFE is associated with prior intubation and inhaled corticosteroids usage. |
| Databáze: | OpenAIRE |
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