Single oral dose safety of D-allulose in dogs
| Autor: | Tatsuya Matsubara, Satoshi Takashima, Toru Nomizo, Masayuki Tokuda, Hitoshi Kitagawa, Naohito Nishii |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
safety Blood Glucose Diarrhea Male medicine.medical_specialty Veterinary medicine Vomiting media_common.quotation_subject medicine.medical_treatment Administration Oral Fructose Placebo Gastroenterology Single oral dose 03 medical and health sciences Dogs Internal medicine medicine Internal Medicine Animals Insulin oral dose Dog Diseases D-allulose rare sugar media_common General Veterinary business.industry Appetite Note 030104 developmental biology Sweetening Agents Toxicity dog Alkaline phosphatase Female medicine.symptom business |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| Popis: | Healthy dogs were administered acute oral doses of D-allulose (also called D-psicose) to evaluate its toxicity. Six dogs received oral doses of either a placebo or D-allulose solution (1 and 4 g/kg) on three different study days. One dog experienced vomiting, and five dogs showed transient diarrhea when 4 g/kg of D-allulose was administered. All dogs were active and had a good appetite throughout the study period. Blood glucose concentration slightly decreased without a rise in plasma insulin concentration 2 hr after D-allulose administration. Plasma alkaline phosphatase activities showed a mild increase between 12 and 48 hr after D-allulose administration. These data suggested that a single oral dose of D-allulose does not show severe toxicity in dogs. |
| Databáze: | OpenAIRE |
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