Respiratory effects of cyclic AMP following injection into the nucleus tractus solitarius of rats
| Autor: | Eugene P. Schoener, P. M. Polasek, Lori Simpson, M. Parizon, Robin A. Barraco, C. J. Janusz |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Bradycardia
Male 8-Bromo Cyclic Adenosine Monophosphate Blood Pressure Injections Cellular and Molecular Neuroscience Heart Rate Heart rate Medicine Animals Respiratory system Tidal volume Pharmacology business.industry Solitary nucleus Respiration Rats Inbred Strains Rats Respiratory Function Tests Anesthesia Medulla oblongata Brainstem medicine.symptom business Respiratory minute volume Brain Stem |
| Zdroj: | Neuropharmacology. 27(12) |
| ISSN: | 0028-3908 |
| Popis: | Rats were anesthetized with urethane and a limited occipital craniotomy was performed to expose the caudal medulla in the region of the obex. Injections were made into sites in the brainstem of spontaneously-breathing rats through glass micropipettes. Tidal volume, respiratory frequency, minute volume, blood pressure and heart rate were recorded before and after the administration of 8-bromoadenosine 3',5'-cyclic monophosphate (Br-cAMP), an analog of cyclic AMP. Injections of Br-cAMP into the ventromedial portion of the caudal nucleus tractus solitarius (NTS) produced dose-related decreases in pulmonary ventilation due to effects on both respiratory frequency, as well as minute volume. In larger doses, Br-cAMP produced periodic apnea and irregular breathing. The respiratory depression was accompanied by transient hypotension and bradycardia. The data indicate that cyclic AMP may function as a second messenger in respiratory control regions in the brainstem. |
| Databáze: | OpenAIRE |
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