Reactivity of proximal and distal angiographically normal and stenotic coronary segments in chronic stable angina pectoris
| Autor: | Peter Bogaty, Juan Carlos Kaski, Stavros Gavrielides, Dimitris Tousoulis, Filippo Crea, Attilio Maseri, Alfredo R. Galassi |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Vasodilation Constriction Pathologic Isosorbide Dinitrate Coronary Angiography Chronic stable angina Angina Pectoris Coronary artery disease Internal medicine medicine Humans Ergonovine business.industry Quantitative angiography Coronary arteriography Middle Aged medicine.disease Coronary Vessels Vasoconstriction Cardiology Female medicine.symptom Isosorbide dinitrate Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American journal of cardiology. 67(15) |
| ISSN: | 0002-9149 |
| Popis: | To assess whether vasoreactivity of significant coronary stenosis (greater than 50% intraluminal diameter reduction) and that of angiographically normal coronary segments differs in proximal and distal locations, 53 patients (40 men, 13 women, mean +/- standard deviation age 55 +/- 11 years) with chronic stable angina and angiographically documented coronary artery disease were studied. While abstaining from antianginal therapy, all 53 patients underwent coronary arteriography before and after 1 mg of intracoronary isosorbide dinitrate and 21 of the 53 also before and after 20 to 30 micrograms intracoronary ergonovine. Computerized quantitative angiography was used to assess changes in the intraluminal diameter of 126 normal coronary segments (63 proximal, 63 distal) and 43 significant coronary stenoses. Nitrates dilated proximal normal coronary segments by 7.4 +/- 1.2% and distal normal coronary segments by 15 +/- 1.7% (p less than 0.01). Significant proximal coronary stenoses dilated by 11 +/- 2.5% and distal stenoses by 23 +/- 2.8% (p less than 0.01) after nitrates. Ergonovine reduced the diameter of proximal normal coronary segments by 9.3 +/- 1.7% and that of normal distal segments by 15.5 +/- 1.4% (p less than 0.01). Proximal stenoses constricted by 11 +/- 2.2% and distal stenoses by 18.4 +/- 2.8% (p = 0.06). Analysis of segments showed that nitrates dilated 19 of 63 (30%) proximal normal segments by (greater than or equal to 10%), 31 of 63 (49%) distal (p less than 0.05) and 21 of 43 (49%) stenoses.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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