Dystroglycan Suppresses Notch to Regulate Stem Cell Niche Structure and Function in the Developing Postnatal Subventricular Zone
| Autor: | Himanshu Sharma, Freyja K. McClenahan, Christopher Eyermann, Xiwei Shan, Holly Colognato |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Neurogenesis animal diseases Cellular differentiation Subventricular zone Biology Article General Biochemistry Genetics and Molecular Biology Dystroglycans Mice 03 medical and health sciences Neural Stem Cells Lateral Ventricles medicine Dystroglycan Animals Stem Cell Niche Progenitor cell Molecular Biology Cell Proliferation Neurons Receptors Notch Cell Differentiation Cell Biology Neural stem cell Radial glial cell Extracellular Matrix Rats Cell biology 030104 developmental biology medicine.anatomical_structure nervous system Cancer research biology.protein Neuroglia Developmental Biology |
| Zdroj: | Dev Cell |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/j.devcel.2016.07.017 |
| Popis: | While the extracellular matrix (ECM) is known to regulate neural stem cell quiescence in the adult subventricular zone (SVZ), the function of ECM in the developing SVZ remains unknown. Here, we report that the ECM receptor dystroglycan regulates a unique developmental restructuring of ECM in the early postnatal SVZ. Dystroglycan is furthermore required for ependymal cell differentiation and assembly of niche pinwheel structures, at least in part by suppressing Notch activation in radial glial cells, which leads to the increased expression of MCI, Myb, and FoxJ1, transcriptional regulators necessary for acquisition of the multiciliated phenotype. Dystroglycan also regulates perinatal radial glial cell proliferation and transition into intermediate gliogenic progenitors, such that either acute or constitutive loss of function in dystroglycan results in increased oligodendrogenesis. These findings reveal a role for dystroglycan in orchestrating both the assembly and function of the SVZ neural stem cell niche. |
| Databáze: | OpenAIRE |
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