Leuprolide acetate induces structural and functional recovery of injured spinal cord in rats
| Autor: | Díaz Galindo C, Bautista E, Eva Salinas, Irma Hernández-Jasso, Beatriz Gómez-González, José Luis Quintanar, Denisse Calderón-Vallejo |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class medicine.medical_treatment microglia micturition reflex Gonadotropin-releasing hormone gait lcsh:RC346-429 Lesion Developmental Neuroscience leuprolide acetate Spinal cord compression Internal medicine medicine gonadotropin-releasing hormone nerve regeneration neurotrophic factor Saline Spinal cord injury lcsh:Neurology. Diseases of the nervous system business.industry spinal cord injury inflammation neural regeneration Spinal cord medicine.disease medicine.anatomical_structure Endocrinology Reflex medicine.symptom business Research Article |
| Zdroj: | Neural Regeneration Research, Vol 10, Iss 11, Pp 1819-1824 (2015) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | Gonadotropin-releasing hormone (GnRH) and its synthetic analog leuprolide acetate, a GnRH agonist, have neurotrophic properties. This study was designed to determine whether administration of leuprolide acetate can improve locomotor behavior, gait, micturition reflex, spinal cord morphology and the amount of microglia in the lesion epicenter after spinal cord injury in rats. Rats with spinal cord compression injury were administered leuprolide acetate or saline solution for 5 weeks. At the 5(th) week, leuprolide acetate-treated rats showed locomotor activity recovery by 38%, had improvement in kinematic gait and exhibited voiding reflex recovery by 60%, as compared with the 1(st) week. By contrast, saline solution-treated rats showed locomotor activity recovery only by 7%, but voiding reflex did not recover. More importantly, leuprolide acetate treatment reduced microglial immunological reaction and induced a trend towards greater area of white and gray matter in the spinal cord. Therefore, leuprolide acetate has great potential to repair spinal cord injury. |
| Databáze: | OpenAIRE |
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