Mycophenolate mofetil for the treatment of acute and chronic steroid-refractory graft-versus-host disease
| Autor: | Michael Doubek, Marta Krejčí, Yvona Brychtová, Jiri Vorlicek, Tomáš Büchler, Jiri Mayer |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Graft vs Host Disease Salvage therapy Gastroenterology Refractory Recurrence immune system diseases Internal medicine medicine Humans Transplantation Homologous Adverse effect Salvage Therapy Peripheral Blood Stem Cell Transplantation Leukemia Hematology business.industry General Medicine Middle Aged Mycophenolic Acid medicine.disease Surgery Transplantation Regimen surgical procedures operative Graft-versus-host disease Methylprednisolone Acute Disease Chronic Disease Drug Evaluation Female business Immunosuppressive Agents medicine.drug |
| Zdroj: | Annals of Hematology. 84:681-685 |
| ISSN: | 1432-0584 0939-5555 |
| DOI: | 10.1007/s00277-005-1070-0 |
| Popis: | Corticosteroid-resistant graft-versus-host disease (GvHD) is difficult to manage and is associated with high morbidity and mortality. The purpose of our study was to evaluate the safety and efficacy of mycophenolate mofetil (MMF) as the salvage therapy for steroid-refractory GvHD. Twenty one patients (10 with acute GvHD and 11 with chronic GvHD) were studied retrospectively. Steroid-resistant GvHD was defined as acute or chronic GvHD not responding to a first-line regimen of cyclosporine A and corticosteroids in a dose equivalent to 2 mg/kg methylprednisolone for at least 7 days. MMF was added at a dose of 2 g daily, and corticosteroids were tapered. Thirteen (62%) of 21 patients responded to the treatment with MMF, including 6 (60%) of 10 patients with acute refractory GvHD and 7 (64%) of 11 patients with chronic refractory GvHD. The most common adverse effects were infectious complications (67%, 14 of 21 patients) and hematological toxicity (29%, 6 of 21 patients). Median duration of MMF administration was 6 months (range 1-27 months). Sixteen of 21 patients were alive after the median follow-up of 27 months (range 1-72 months) after the initiation of MMF therapy. All 16 surviving patients were in good clinical condition and in remission of their hematological malignancy. Five patients died--two of relapses of leukemia and three of refractory intestinal GvHD. These results suggest that MMF can be an effective treatment for some cases of steroid-refractory GvHD. |
| Databáze: | OpenAIRE |
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