Ventral medial prefrontal cortex (vmPFC) as a target of the dorsolateral prefrontal modulation by transcranial direct current stimulation (tDCS) in drug addiction

Autor: Rodrigo Stênio Moll de Souza, Edson Kruger Batista, Isabela Bittencourt Coutinho Lopes, Catarine Lima Conti, Rodolpho Albuquerque Souza, Janine Andrade Moscon, Ester Miyuki Nakamura-Palacios, Jaisa Klauss
Rok vydání: 2016
Předmět:
Adult
Male
Substance-Related Disorders
medicine.medical_treatment
media_common.quotation_subject
Prefrontal Cortex
Craving
Nucleus accumbens
Electroencephalography
Transcranial Direct Current Stimulation
behavioral disciplines and activities
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Neural Pathways
Outpatients
mental disorders
Fractional anisotropy
Image Processing
Computer-Assisted
medicine
Humans
Prefrontal cortex
Biological Psychiatry
media_common
medicine.diagnostic_test
Transcranial direct-current stimulation
Addiction
Middle Aged
030227 psychiatry
Dorsolateral prefrontal cortex
Psychiatry and Mental health
Diffusion Tensor Imaging
medicine.anatomical_structure
Neurology
Linear Models
Female
Neurology (clinical)
Cues
medicine.symptom
Psychology
Neuroscience
Photic Stimulation
psychological phenomena and processes
030217 neurology & neurosurgery
Zdroj: Journal of Neural Transmission. 123:1179-1194
ISSN: 1435-1463
0300-9564
DOI: 10.1007/s00702-016-1559-9
Popis: Here, we report some electrophysiologic and imaging effects of the transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (dlPFC) in drug addiction, notably in alcohol and crack-cocaine dependence. The low resolution electromagnetic tomography (LORETA) analysis obtained through event-related potentials (ERPs) under drug-related cues, more specifically in its P3 segment (300-500 ms) in both, alcoholics and crack-cocaine users, showed that the ventral medial prefrontal cortex (vmPFC) was the brain area with the largest change towards increasing activation under drug-related cues in those subjects that kept abstinence during and after the treatment with bilateral tDCS (2 mA, 35 cm(2), cathodal left and anodal right) over dlPFC, applied repetitively (five daily sessions). In an additional study in crack-cocaine, which showed craving decreases after repetitive bilateral tDCS, we examined data originating from diffusion tensor imaging (DTI), and we found increased DTI parameters in the left connection between vmPFC and nucleus accumbens (NAcc), such as the number of voxels, fractional anisotropy (FA) and apparent diffusion coefficient (ADC), in tDCS-treated crack-cocaine users when compared to the sham-tDCS group. This increasing of DTI parameters was significantly correlated with craving decreasing after the repetitive tDCS. The vmPFC relates to the control of drug seeking, possibly by extinguishing this behavior. In our studies, the bilateral dlPFC tDCS reduced relapses and craving to the drug use, and increased the vmPFC activation under drug cues, which may be of a great importance in the control of drug use in drug addiction.
Databáze: OpenAIRE
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