A study on the correlation of G-protein-coupled receptor types with amino acid composition
| Autor: | David W. Elrod, Kuo-Chen Chou |
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| Rok vydání: | 2002 |
| Předmět: |
Models
Molecular Training set Drug discovery Bioengineering Genomics Receptors Cell Surface Biology Protein Engineering Biochemistry Correlation Amino acid composition GTP-Binding Proteins Drug Design Amino Acids Receptor Databases Protein Molecular Biology Algorithms Biotechnology G protein-coupled receptor |
| Zdroj: | Protein engineering. 15(9) |
| ISSN: | 0269-2139 |
| Popis: | G-protein-coupled receptors have become a target in utilizing bioinformatics and genomics technology to facilitate drug discovery for psychiatric diseases. In this study the covariant-discriminant algorithm [Chou and Elrod (1999) Protein Eng., 12, 107-118] has been used to analyze the correlation between the types of G-protein-coupled receptors and the amino acid composition. It has been found that different types of G-protein-coupled receptors are quite closely correlated with the amino acid composition, implying that the types of G-protein-coupled receptors are predictable to a considerably accurate extent if a good training data set can be established for that purpose. The method derived here can be also used to do preliminary classification of orphan G-protein-coupled receptors. This will significantly expedite the process of identifying proper G-protein-coupled receptors for drug discovery. |
| Databáze: | OpenAIRE |
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