Altered Monoamine Metabolism in the Hypothalamus of the Genetically Obese Yellow (Ay/a) Mouse
| Autor: | Kouji Kashima, Isao Kobayashi, S. Takahashi, Y. Shimomura, Y. Uehara, Hiroyuki Shimizu, Yoshito Tanaka, Akira Fukatsu, Masaki Takahashi, Mayumi Negishi |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Ratón Dopamine Endocrinology Diabetes and Metabolism Hypothalamus Mice Obese Biology Methoxyhydroxyphenylglycol Mice Norepinephrine Endocrinology Internal medicine Internal Medicine medicine Animals Biogenic Monoamines Body Weight General Medicine medicine.disease Obesity Monoamine metabolism Monoamine neurotransmitter medicine.symptom Weight gain medicine.drug |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 99:45-48 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0029-1211131 |
| Popis: | Changes in hypothalamic monoamine metabolism were investigated in the genetically obese yellow (Ay/a) mouse. At the age of 6 weeks when there was no difference in body weight between black (a/a) and yellow (Ay/a) mice, the contents of norepinephrine (NE), dopamine (DA) and their main metabolites (MHPG, DOPAC) were already significantly reduced in yellow (Ay/a) mice. Reduction of 5-hydroxytryptamine (5-HT) level and an increasing 5-HIAA/5-HT ratio has been observed. When a significant increase in body weight in the yellow (Ay/a) mouse at the age of 12 weeks was present, both NE and DA contents have been increased in the hypothalamus of the obese mouse. MHPG level was lower than in the lean mouse, resulting in an increase of MHPG/NE ratio. The present study suggests that the observed reduction in hypothalamic NE and DA metabolism might be involved in the development of overweight gain in the yellow (Ay/a) mouse. |
| Databáze: | OpenAIRE |
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