Rituximab Treatment for Chronic Idiopathic Axonal Polyneuropathy
| Autor: | Hussein Moussa, Raja A. Sawaya |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Weakness medicine.medical_treatment Neural Conduction Electromyography 030105 genetics & heredity Axonal polyneuropathy Polyneuropathies 03 medical and health sciences 0302 clinical medicine Sural Nerve medicine Humans Immunologic Factors Induction dose Neurologic Examination medicine.diagnostic_test business.industry General Medicine Hand Axons Muscle atrophy Neurology Anesthesia Etiology Administration Intravenous Rituximab Plasmapheresis Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Clinical Neuromuscular Disease. 22:214-219 |
| ISSN: | 1522-0443 |
| DOI: | 10.1097/cnd.0000000000000328 |
| Popis: | Chronic idiopathic axonal polyneuropathy is a disorder of unknown etiology resulting in progressive weakness and sensory disturbances predominantly in the hands and feet. Nerve conduction studies and electromyography confirm axonal damage in the nerves of the upper and lower extremities. The pathology is symmetrical with a distal predilection. Patients usually do not respond to the classical treatment with steroids, intravenous immunoglobulin, plasmapheresis, or immunosuppressant drugs. We describe 2 cases of chronic idiopathic axonal polyneuropathy who received intravenous rituximab as a last resort because of the severity of their symptoms. Both patients showed dramatic improvement in their weakness, muscle atrophy, numbness, and paresthesias only few weeks after the induction dose. Their daily functional activities improved to self-independence. |
| Databáze: | OpenAIRE |
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