Protection from light damage by ocular pigmentation: Analysis using experimental chimeras and translocation mice
| Autor: | Gregg M. Gorrin, Matthew M. LaVail |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Retinal degeneration
Pathology medicine.medical_specialty Light Mice Inbred Strains Chromosomal translocation Biology Retina Melanin Mice Cellular and Molecular Neuroscience chemistry.chemical_compound Chimera (genetics) medicine Animals Photoreceptor Cells Pigment Epithelium of Eye Melanosome Melanins Retinal pigment epithelium Eye Color Chimera Retinal medicine.disease eye diseases Sensory Systems Cell biology Ophthalmology medicine.anatomical_structure chemistry sense organs |
| Zdroj: | Experimental Eye Research. 44:877-889 |
| ISSN: | 0014-4835 |
| DOI: | 10.1016/s0014-4835(87)80050-7 |
| Popis: | Experimental mouse chimeras and Cattanach's translocation mice, both with alternating pigmented and non-pigmented cells of the retinal pigment epithelium (RPE), have been exposed to various periods of constant fluorescent light. Photoreceptor degeneration was always more severe in the central retina than in the peripheral retina, and it was independent of the pigmentation phenotype of the immediately overlying RPE. The findings suggest that although RPE melanosomes lower total retinal irradiance by absorption of light, they do not provide direct protection from light damage for the immediately underlying photoreceptor cells by a biochemical mechanism as previously suggested. |
| Databáze: | OpenAIRE |
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