A randomized controlled trial to evaluate omentum-preserving gastrectomy for patients with T1–T3 gastric cancer

Autor: Ming-Min Chen, Zhenqiang Wang, Zhongyin Yang, Wentao Liu, Birendra Kumar Sah, Zhentian Ni, Chen Li, Chao Yan, Xuexin Yao, Yanan Zheng, Zhenglun Zhu, Min Yan, Zhenggang Zhu, Sheng Lu, Changyu He, Zichen Hua, Runhua Feng
Rok vydání: 2021
Předmět:
Adult
Male
Cancer Research
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Disease-Free Survival
law.invention
Young Adult
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Gastrectomy
Stomach Neoplasms
law
medicine
Humans
Prospective Studies
Aged
Neoplasm Staging
Randomized Controlled Trials as Topic
Retrospective Studies
business.industry
Incidence (epidemiology)
Cancer
Retrospective cohort study
General Medicine
Middle Aged
Greater omentum
Prognosis
medicine.disease
digestive system diseases
Surgery
Survival Rate
body regions
Clinical trial
Omentectomy
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Lymph Node Excision
Female
030211 gastroenterology & hepatology
Neoplasm Recurrence
Local
business
Omentum
Organ Sparing Treatments
Zdroj: Future Oncology. 17:3301-3307
ISSN: 1744-8301
1479-6694
DOI: 10.2217/fon-2021-0240
Popis: Although complete omentectomy is traditionally performed in patients with gastric cancer as part of radical gastrectomy to ensure the elimination of micrometastases, the prognostic value of omentectomy during gastrectomy remains unclear. Retrospective studies have shown that the incidence of metastases in the greater omentum is very low in T1–T3 gastric cancer. Thus radical gastrectomy with D2 lymphadenectomy and preservation of the greater omentum may be a proper curative treatment for gastric cancer patients with T1–T3 tumors. The aim of this article is to describe the design and rationale for this prospective, randomized controlled DRAGON-05 trial, conducted to evaluate the prognostic value of omentum-preserving gastrectomy for patients with T1–T3 gastric cancer. Clinical trial registration: ChiCTR2000040045 (ClinicalTrials.gov)
Databáze: OpenAIRE
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