Genome-wide association study identifies 74 loci associated with educational attainment

Autor: K. Petrovic, Massimo Mangino, Daniele Cusi, Ozren Polasek, Rodney J. Scott, Yong Qian, Aysu Okbay, Jari Lahti, Bjarni Gunnarsson, George McMahon, Elizabeth G. Holliday, Thomas Meitinger, Frank J. A. van Rooij, Mika Kähönen, Martin Kroh, Ian J. Deary, Neil Pendleton, Pamela A. F. Madden, David J. Porteous, Lambertus A. Kiemeney, Sven Oskarsson, Edith Hofer, Robert F. Krueger, Olga Rostapshova, Georg Homuth, Paolo Gasparini, Aldo Rustichini, Sarah E. Medland, Christian Gieger, Veronique Vitart, Nicholas J. Timpson, George Dedoussis, Joseph K. Pickrell, Christopher Oldmeadow, Aldi T. Kraja, Johan G. Eriksson, Lydia Quaye, William G. Iacono, Danielle Posthuma, George Davey Smith, Karl-Oskar Lindgren, David C. Liewald, Pim van der Harst, Börge Schmidt, Christine Power, Francesco P. Cappuccio, Francesco Cucca, Simona Vaccargiu, Joyce Y. Tung, Aarno Palotie, Natalia Pervjakova, Jonas Bacelis, Jouke-Jan Hottenga, Helena Schmidt, Kari Stefansson, Tamara B. Harris, Momoko Horikoshi, Lude Franke, Wolfgang Hoffmann, Ingrid B. Borecki, William E R Ollier, Johannes Waage, Andreas J. Forstner, Caroline Hayward, Penelope A. Lind, Patricia A. Boyle, Kadri Kaasik, Jian Yang, Gerardus A. Meddens, Antti Latvala, John Attia, Pascal Timshel, Vilmundur Gudnason, Maël Lebreton, Valur Emilsson, James F. Wilson, Jonathan Marten, Ute Bültmann, Erika Salvi, Olli T. Raitakari, Peter M. Visscher, Niek Verweij, Elisabeth Steinhagen-Thiessen, Cristina Venturini, Lili Milani, Tessel E. Galesloot, Kevin Thom, Klaus Berger, Paul Lichtenstein, Tian Liu, Philipp Koellinger, Riccardo E. Marioni, Marjo-Riitta Järvelin, Clemens Baumbach, Unnur Thorsteinsdottir, Magnus Johannesson, Susan M. Ring, David A. Bennett, Anu Loukola, Hans-Jörgen Grabe, Jan A. Staessen, Igor Rudan, Ginevra Biino, Nicholas G. Martin, Jingyun Yang, Anna A. E. Vinkhuyzen, Katri Räikkönen, Zhihong Zhu, Gudmar Thorleifsson, Mary F. Feitosa, Ivana Kolcic, Alexander Teumer, Jaakko Kaprio, David Schlessinger, Katharina E. Schraut, Konstantin Strauch, Ilja Demuth, Albert V. Smith, Juergen Wellmann, Jennifer E. Huffman, Panos Deloukas, Mario Pirastu, Reedik Mägi, Maria Pina Concas, Jaime Derringer, Patrick J. F. Groenen, Henry Völzke, Wei Zhao, Abdel Abdellaoui, Andres Metspalu, Nicholas A. Furlotte, Christopher P. Nelson, Barbara Franke, Steven F. Lehrer, Patrick Turley, Tõnu Esko, Jun Ding, Pedro Marques-Vidal, S. Fleur W. Meddens, Zoltán Kutalik, Gonneke Willemsen, Andrew C. Heath, Michelle N. Meyer, James J. Lee, Roy Thurik, Antonietta Robino, Henning Tiemeier, Grant W. Montgomery, C. deLeeuw, Astanand Jugessur, Antti-Pekka Sarin, Veikko Salomaa, Dalton Conley, Tim D. Spector, Sebastian E. Baumeister, Gyda Bjornsdottir, Lavinia Paternoster, Tune H. Pers, Jacob Gratten, Martin D. Tobin, Daniel J. Benjamin, Douglas F. Levinson, Stavroula Kanoni, Elina Hyppönen, David R. Weir, Peter J. van der Most, Terho Lehtimäki, David A. Hinds, Pablo V. Gejman, Uwe Völker, Cornelia M. van Duijn, Karl-Heinz Jöckel, Bjarni V. Halldorsson, Markus Perola, Nicola Pirastu, Klaus Bønnelykke, Robert Karlsson, David Cesarini, Michael A. Province, Jianxin Shi, Najaf Amin, Dale R. Nyholt, Lenore J. Launer, Nilesh J. Samani, Sven J. van der Lee, Dorret I. Boomsma, Harry Campbell, Peter Vollenweider, Liisa Keltigangas-Jarvinen, David Laibson, Ronald de Vlaming, Lynne J. Hocking, Christopher F. Chabris, Blair H. Smith, Gail Davies, Niina Eklund, Ioanna P. Kalafati, Bo Jacobsson, Sheila Ulivi, Alan F. Wright, Sarah E. Harris, Mark Alan Fontana, Diego Vozzi, Tomi Mäki-Opas, Albert Hofman, Hans Bisgaard, Andrew Bakshi, Marika Kaakinen, Johannes H. Brandsma, Christa Meisinger, Ilaria Gandin, Tarunveer S. Ahluwalia, Jennifer A. Smith, Beate St Pourcain, Rico Rueedi, Lewin Eisele, Michael B. Miller, Brenda W.J.H. Penninx, Alan R. Sanders, Thorkild I. A. Sørensen, André G. Uitterlinden, Cornelius A. Rietveld, Peter Lichtner, Dragana Vuckovic, Giorgia Girotto, Behrooz Z. Alizadeh, Reinhold Schmidt, Raymond A. Poot, Judith M. Vonk, Antony Payton, Wouter J. Peyrot, Augustine Kong, Y. Milaneschi, Jessica D. Faul, Patrik K. E. Magnusson, Antonio Terracciano, David M. Evans, Sharon L.R. Kardia, Peter K. Joshi, Michael A. Horan, Matt McGue, Richa Gupta, Jonathan P. Beauchamp, Peter Eibich, Erin B. Ware, Lars Bertram, Philip L. De Jager, Nancy L. Pedersen, Ronny Myhre, Guo-Bo Chen, Harm-Jan Westra, Jan-Emmanuel De Neve, Evelin Mihailov, Leanne M. Hall, Seppo Koskinen
Přispěvatelé: Rush University Medical Center [Chicago], Department of Epidemiology [Rotterdam], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Helmholtz-Zentrum München (HZM), University of Queensland [Brisbane], Erasmus University Rotterdam, Universidad de Navarra [Pamplona] (UNAV), National Institute for Health and Welfare [Helsinki], Institute for Molecular Medicine Finland [Helsinki] (FIMM), Helsinki Institute of Life Science (HiLIFE), Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Consiglio Nazionale delle Ricerche (CNR), Montpellier Research in Management (MRM), Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Perpignan Via Domitia (UPVD)-Groupe Sup de Co Montpellier (GSCM) - Montpellier Business School-Université de Montpellier (UM), University of Bristol [Bristol], Queensland Institute of Medical Research, Massachusetts General Hospital [Boston], Medical University Graz, Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), King‘s College London, Tampere University Hospital, University of Turku, AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Edinburgh, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Imperial College London, Reykjavík University, Donders Institute for Brain, Cognition and Behaviour, Radboud university [Nijmegen], Karolinska Institutet [Stockholm], Department of Health Sciences [Leicester], University of Leicester, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Department of Medical Epidemiology and Biostatistics (MEB), Dpt of Pharmacology and Personalised Medicine [Maastricht], Maastricht University [Maastricht], Florida State University [Tallahassee] (FSU), IT University of Copenhagen, University of Helsinki-University of Helsinki, Université Montpellier 1 (UM1)-Groupe Sup de Co Montpellier (GSCM) - Montpellier Business School-Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Perpignan Via Domitia (UPVD), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Université Sciences et Technologies - Bordeaux 1-Université Montesquieu - Bordeaux 4-Institut de Chimie du CNRS (INC), Faculteit Economie en Bedrijfskunde, Microeconomics (ASE, FEB), LifeLines Cohort Study, Alizadeh, BZ., de Boer, RA., Boezen, HM., Bruinenberg, M., Franke, L., van der Harst, P., Hillege, HL., van der Klauw, MM., Navis, G., Ormel, J., Postma, DS., Rosmalen, JG., Slaets, JP., Snieder, H., Stolk, RP., Wolffenbuttel, BH., Wijmenga, C., Applied Economics, Cell biology, Epidemiology, Erasmus MC other, Econometrics, Child and Adolescent Psychiatry / Psychology, Psychiatry, Internal Medicine, EMGO+ - Mental Health, Complex Trait Genetics, Biological Psychology, Functional Genomics, Economics, Amsterdam Neuroscience - Complex Trait Genetics, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Groningen Research Institute for Asthma and COPD (GRIAC), Public Health Research (PHR), Cardiovascular Centre (CVC), Life Course Epidemiology (LCE), Stem Cell Aging Leukemia and Lymphoma (SALL), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Okbay, Aysu, Beauchamp, Jonathan P., Fontana, Mark Alan, Lee, James J., Pers, Tune H., Rietveld, Cornelius A., Turley, Patrick, Chen, Guo Bo, Emilsson, Valur, Meddens, S. Fleur W., Oskarsson, Sven, Pickrell, Joseph K., Thom, Kevin, Timshel, Pascal, De Vlaming, Ronald, Abdellaoui, Abdel, Ahluwalia, Tarunveer S., Bacelis, Jona, Baumbach, Clemen, Bjornsdottir, Gyda, Brandsma, Johannes H., Concas, MARIA PINA, Derringer, Jaime, Furlotte, Nicholas A., Galesloot, Tessel E., Girotto, Giorgia, Gupta, Richa, Hall, Leanne M., Harris, Sarah E., Hofer, Edith, Horikoshi, Momoko, Huffman, Jennifer E., Kaasik, Kadri, Kalafati, Ioanna P., Karlsson, Robert, Kong, Augustine, Lahti, Jari, Van Der Lee, Sven J., Deleeuw, Christiaan, Lind, Penelope A., Lindgren, Karl Oskar, Liu, Tian, Mangino, Massimo, Marten, Jonathan, Mihailov, Evelin, Miller, Michael B., Van Der Most, Peter J., Oldmeadow, Christopher, Payton, Antony, Pervjakova, Natalia, Peyrot, Wouter J., Qian, Yong, Raitakari, Olli, Rueedi, Rico, Salvi, Erika, Schmidt, Börge, Schraut, Katharina E., Shi, Jianxin, Smith, Albert V., Poot, Raymond A., St Pourcain, Beate, Teumer, Alexander, Thorleifsson, Gudmar, Verweij, Niek, Vuckovic, Dragana, Wellmann, Juergen, Westra, Harm Jan, Yang, Jingyun, Zhao, Wei, Zhu, Zhihong, Alizadeh, Behrooz Z., Amin, Najaf, Bakshi, Andrew, Baumeister, Sebastian E., Biino, Ginevra, Bønnelykke, Klau, Boyle, Patricia A., Campbell, Harry, Cappuccio, Francesco P., Davies, Gail, De Neve, Jan Emmanuel, Deloukas, Pano, Demuth, Ilja, Ding, Jun, Eibich, Peter, Eisele, Lewin, Eklund, Niina, Evans, David M., Faul, Jessica D., Feitosa, Mary F., Forstner, Andreas J., Gandin, Ilaria, Gunnarsson, Bjarni, Halldórsson, Bjarni V., Harris, Tamara B., Holliday, Elizabeth G., Heath, Andrew C., Hocking, Lynne J., Homuth, Georg, Horan, Michael A., Hottenga, Jouke Jan, De Jager, Philip L., Joshi, Peter K., Jugessur, Astanand, Kaakinen, Marika A., Kähönen, Mika, Kanoni, Stavroula, Keltigangas Järvinen, Liisa, Kiemeney, Lambertus A. L. M., Kolcic, Ivana, Koskinen, Seppo, Kraja, Aldi T., Kroh, Martin, Kutalik, Zoltan, Latvala, Antti, Launer, Lenore J., Lebreton, Maël P., Levinson, Douglas F., Lichtenstein, Paul, Lichtner, Peter, Liewald, David C. M., Loukola, Anu, Madden, Pamela A., Mägi, Reedik, Mäki Opas, Tomi, Marioni, Riccardo E., Marques Vidal, Pedro, Meddens, Gerardus A., Mcmahon, George, Meisinger, Christa, Meitinger, Thoma, Milaneschi, Yusplitri, Milani, Lili, Montgomery, Grant W., Myhre, Ronny, Nelson, Christopher P., Nyholt, Dale R., Ollier, William E. R., Palotie, Aarno, Paternoster, Lavinia, Pedersen, Nancy L., Petrovic, Katja E., Porteous, David J., Raïkkönen, Katri, Ring, Susan M., Robino, Antonietta, Rostapshova, Olga, Rudan, Igor, Rustichini, Aldo, Salomaa, Veikko, Sanders, Alan R., Sarin, Antti Pekka, Schmidt, Helena, Scott, Rodney J., Smith, Blair H., Smith, Jennifer A., Staessen, Jan A., Steinhagen Thiessen, Elisabeth, Strauch, Konstantin, Terracciano, Antonio, Tobin, Martin D., Ulivi, Sheila, Vaccargiu, Simona, Quaye, Lydia, Van Rooij, Frank J. A., Venturini, Cristina, Vinkhuyzen, Anna A. E., Völker, Uwe, Völzke, Henry, Vonk, Judith M., Vozzi, Diego, Waage, Johanne, Ware, Erin B., Willemsen, Gonneke, Attia, John R., Bennett, David A., Berger, Klau, Bertram, Lar, Bisgaard, Han, Boomsma, Dorret I., Borecki, Ingrid B., Bültmann, Ute, Chabris, Christopher F., Cucca, Francesco, Cusi, Daniele, Deary, Ian J., Dedoussis, George V., Van Duijn, Cornelia M., Eriksson, Johan G., Franke, Barbara, Franke, Lude, Gasparini, Paolo, Gejman, Pablo V., Gieger, Christian, Grabe, Hans Jörgen, Gratten, Jacob, Groenen, Patrick J. F., Gudnason, Vilmundur, Van Der Harst, Pim, Hayward, Caroline, Hinds, David A., Hoffmann, Wolfgang, Hyppönen, Elina, Iacono, William G., Jacobsson, Bo, Järvelin, Marjo Riitta, Jöckel, Karl Heinz, Kaprio, Jaakko, Kardia, Sharon L. R., Lehtimäki, Terho, Lehrer, Steven F., Magnusson, Patrik K. E., Martin, Nicholas G., Mcgue, Matt, Metspalu, Andre, Pendleton, Neil, Penninx, Brenda W. J. H., Perola, Marku, Pirastu, Nicola, Pirastu, Mario, Polasek, Ozren, Posthuma, Danielle, Power, Christine, Province, Michael A., Samani, Nilesh J., Schlessinger, David, Schmidt, Reinhold, Sørensen, Thorkild I. A., Spector, Tim D., Stefansson, Kari, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Tiemeier, Henning, Tung, Joyce Y., Uitterlinden, André G., Vitart, Veronique, Vollenweider, Peter, Weir, David R., Wilson, James F., Wright, Alan F., Conley, Dalton C., Krueger, Robert F., Davey Smith, George, Hofman, Albert, Laibson, David I., Medland, Sarah E., Meyer, Michelle N., Yang, Jian, Johannesson, Magnu, Visscher, Peter M., Esko, Toñu, Koellinger, Philipp D., Cesarini, David, Benjamin, Daniel J., EMGO - Mental health, IOO, Human genetics, Beauchamp, Jonathan P, Lee, James JJ, Hypponen, Elina, Benjamin, Daniel J
Rok vydání: 2016
Předmět:
0301 basic medicine
Netherlands Twin Register (NTR)
Candidate gene
Bipolar Disorder
Medizin
Genome-wide association study
Genome-wide association studies
0302 clinical medicine
Cognition
Alzheimer Disease
Brain
Computational Biology
Fetus
Gene Expression Regulation
Gene-Environment Interaction
Great Britain
Humans
Molecular Sequence Annotation
Polymorphism
Single Nucleotide
Schizophrenia
Educational Status
Genome-Wide Association Study
Medicine (all)
Multidisciplinary
Fetu
tau
Gene–environment interaction
Soziales und Gesundheit
Genetics
[QFIN]Quantitative Finance [q-fin]
HERITABILITY
General Commentary
Alzheimer's disease
Biobank
Phenotype
Multidisciplinary Sciences
Urological cancers Radboud Institute for Health Sciences [Radboudumc 15]
educational attainment
Behavioural genetics
Science & Technology - Other Topics
Bildungsniveau
TRAITS
Human
General Science & Technology
Kultursektor
SNP
ta3111
Polymorphism
Single Nucleotide
Learning and memory
Alzheimer Disease/genetics
Bipolar Disorder/genetics
Brain/metabolism
Fetus/metabolism
Gene Expression Regulation/genetics
Polymorphism
Single Nucleotide/genetics
Schizophrenia/genetics
03 medical and health sciences
ACHIEVEMENT
MD Multidisciplinary
Non-Profit-Sektor
QH426
Science & Technology
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
tauopathies
Data Science
gene
education
school
Heritability
Educational Statu
Educational attainment
United Kingdom
030104 developmental biology
IQ
Genetische Forschung
Psychiatric disorders
Bildung
030217 neurology & neurosurgery
LifeLines Cohort Study
Neuroscience
Zdroj: Nature
Frontiers in Molecular Neuroscience
2016, ' Genome-wide association study identifies 74 loci associated with educational attainment ', Nature, vol. 533, no. 7604, pp. 539-542 . https://doi.org/10.1038/nature17671
Nature, Nature Publishing Group, 2016, 533 (7604), pp.539-542. ⟨10.1038/nature17671⟩
Nature, Nature Publishing Group, 2016, 533 (7604), pp.539--542. ⟨10.1038/nature17671⟩
Nature, 533, 539-42
Okbay, A, P. Beauchamp, J, Alan Fontana, M, J. Lee, J, H. Pers, T, A. Rietveld, C, Turley, P, Chen, G-B, Emilsson, V, Fleur W. Meddens, S, S. Ahluwalia, T, Sørensen, T I A, Timshel, P, Bønnelykke, K, Waage, J, Bisgaard, H & I. A. Sørensen, T 2016, ' Genome-wide association study identifies 74 loci associated with educational attainment ', Nature, vol. 533, no. 7604, pp. 539-542 . https://doi.org/10.1038/nature17671
Okbay, A, Beauchamp, J P, Fontana, M A, Lee, J J, Pers, T H, Rietveld, C A, Turley, P, Chen, G-B, Emilsson, V, Meddens, S F W, Oskarsson, S, Pickrell, J K, Thom, K, Timshel, P, de Vlaming, R, Abdellaoui, A, Ahluwalia, T S, Bacelis, J, Baumbach, C, Bjornsdottir, G, Brandsma, J H, Pina Concas, M, Derringer, J, Furlotte, N A, Galesloot, T E, Girotto, G, Gupta, R, Hall, L M, Harris, S E, Hofer, E, Horikoshi, M, Huffman, J E, Kaasik, K, Kalafati, I-P, Karlsson, R, Kong, A, Lahti, J, van der Lee, S J, deLeeuw, C, Lind, P A, Lindgren, K-O, Liu, T, Payton, A, Horan, M A, Ollier, W E R, Smith, J A, Bennett, D A, Martin, N G, Pendleton, N, Wilson, J F & LifeLines Cohort Study 2016, ' Genome-wide association study identifies 74 loci associated with educational attainment ', Nature-London-, vol. 533, no. 7604, pp. 539-42 . https://doi.org/10.1038/nature17671
Nature, 533(7604), 539-542. Nature Publishing Group
Nature, vol. 533, no. 7604, pp. 539-542
Okbay, A, Beauchamp, J, Fontana, M A, Lee, J J, Pers, T H, Rietveld, C A, Turley, P, Chen, G B, Emilsson, V, Meddens, S F W, de Vlaming, R, Abdellaoui, A, Peyrot, W, Vinkhuyzen, A A E, Hottenga, J J, Willemsen, G, Boomsma, D I, Penninx, B W J H, Laibson, D, Medland, S E, Meyer, M N, Yang, J, Johannesson, M, Visscher, P M, Esko, T, Koellinger, P D, Cesarini, D & Benjamin, D J 2016, ' Genome-wide association study identifies 74 loci associated with educational attainment ', Nature, vol. 533, no. 7604, pp. 539-542 . https://doi.org/10.1038/nature17671
Nature (Lond.) 533 (2016): 539–542. doi:10.1038/nature17671
info:cnr-pdr/source/autori:Okbay A, Beauchamp JP, Fontana MA, Lee JJ, Pers TH, Rietveld CA, Turley P, Chen GB, Emilsson V, Meddens SF, Oskarsson S, Pickrell JK, Thom K, Timshel P, de Vlaming R, Abdellaoui A, Ahluwalia TS, Bacelis J, Baumbach C, Bjornsdottir G, Brandsma JH, Pina Concas M, Derringer J, Furlotte NA, Galesloot TE, Girotto G, Gupta R, Hall LM, Harris SE, Hofer E, Horikoshi M, Huffman JE, Kaasik K, Kalafati IP, Karlsson R, Kong A, Lahti J, van der Lee SJ, deLeeuw C, Lind PA, Lindgren KO, Liu T, Mangino M, Marten J, Mihailov E, Miller MB, van der Most PJ, Oldmeadow C, Payton A, Pervjakova N, Peyrot WJ, Qian Y, Raitakari O, Rueedi R, Salvi E, Schmidt B, Schraut KE, Shi J, Smith AV, Poot RA, St Pourcain B, Teumer A, Thorleifsson G, Verweij N, Vuckovic D, Wellmann J, Westra HJ, Yang J, Zhao W, Zhu Z, Alizadeh BZ, Amin N, Bakshi A, Baumeister SE, Biino G, Bønnelykke K, Boyle PA, Campbell H, Cappuccio FP, Davies G, De Neve JE, Deloukas P, Demuth I, Ding J, Eibich P, Eisele L, Eklund N, Evans DM, Faul JD, Feitosa MF, Forstner AJ, Gandin I, Gunnarsson B, Halldórsson BV, Harris TB, Heath AC, Hocking LJ, Holliday EG, Homuth G, Horan MA, Hottenga JJ, de Jager PL, Joshi PK, Jugessur A, Kaakinen MA, Kähönen M, Kanoni S, Keltigangas-Järvinen L, Kiemeney LA, Kolcic I, Koskinen S, Kraja AT, Kroh M, Kutalik Z, Latvala A, Launer LJ, Lebreton MP, Levinson DF, Lichtenstein P, Lichtner P, Liewald DC; LifeLines Cohort Study, Loukola A, Madden PA, Mägi R, Mäki-Opas T, Marioni RE, Marques-Vidal P, Meddens GA, McMahon G, Meisinger C, Meitinger T, Milaneschi Y, Milani L, Montgomery GW, Myhre R, Nelson CP, Nyholt DR, Ollier WE, Palotie A, Paternoster L, Pedersen NL, Petrovic KE, Porteous DJ, Räikkönen K, Ring SM, Robino A, Rostapshova O, Rudan I, Rustichini A, Salomaa V, Sanders AR, Sarin AP, Schmidt H, Scott RJ, Smith BH, Smith JA, Staessen JA, Steinhagen-Thiessen E, Strauch K, Terracciano A, Tobin MD, Ulivi S, Vaccargiu S, Quaye L, van Rooij FJ, Venturini C, Vinkhuyzen AA, Völker U, Völzke H, Vonk JM, Vozzi D, Waage J, Ware EB, Willemsen G, Attia JR, Bennett DA, Berger K, Bertram L, Bisgaard H, Boomsma DI, Borecki IB, Bültmann U, Chabris CF, Cucca F, Cusi D, Deary IJ, Dedoussis GV, van Duijn CM, Eriksson JG, Franke B, Franke L, Gasparini P, Gejman PV, Gieger C, Grabe HJ, Gratten J, Groenen PJ, Gudnason V, van der Harst P, Hayward C, Hinds DA, Hoffmann W, Hyppönen E, Iacono WG, Jacobsson B, Järvelin MR, Jöckel KH, Kaprio J, Kardia SL, Lehtimäki T, Lehrer SF, Magnusson PK, Martin NG, McGue M, Metspalu A, Pendleton N, Penninx BW, Perola M, Pirastu N, Pirastu M, Polasek O, Posthuma D, Power C, Province MA, Samani NJ, Schlessinger D, Schmidt R, Sørensen TI, Spector TD, Stefansson K, Thorsteinsdottir U, Thurik AR, Timpson NJ, Tiemeier H, Tung JY, Uitterlinden AG, Vitart V, Vollenweider P, Weir DR, Wilson JF, Wright AF, Conley DC, Krueger RF, Davey Smith G, Hofman A, Laibson DI, Medland SE, Meyer MN, Yang J, Johannesson M, Visscher PM, Esko T, Koellinger PD, Cesarini D, Benjamin DJ/titolo:Genome-wide association study identifies 74 loci associated with educational attainment/doi:10.1038%2Fnature17671/rivista:Nature (Lond.)/anno:2016/pagina_da:539/pagina_a:542/intervallo_pagine:539–542/volume:533
Nature, 533, 539-542
Nature, 533(7604), 539-554. Nature Publishing Group
Nature, 533, 7604, pp. 539-542
Nature 533, 539-542 (2016)
Okbay, A, Beauchamp, J P, Fontana, M A, Lee, J J, Pers, T H, Rietveld, C A, Turley, P, Chen, G-B, Emilsson, V, Meddens, S F W, Oskarsson, S, Pickrell, J K, Thom, K, Timshel, P, de Vlaming, R, Abdellaoui, A, Ahluwalia, T S, Bacelis, J, Baumbach, C, Bjornsdottir, G, Brandsma, J H, Concas, M P, Derringer, J, Furlotte, N A, Galesloot, T E, Girotto, G, Gupta, R, Hall, L M, Harris, S E, Hofer, E, Horikoshi, M, Huffman, J E, Kaasik, K, Kalafati, I P, Karlsson, R, Kong, A, Lahti, J, van der Lee, S J, de Leeuw, C, Lind, P A, Lindgren, K-O, Liu, T, Mangino, M, Marten, J, Mihailov, E, Miller, M B, van der Most, P J, Oldmeadow, C, Payton, A, Pervjakova, N, Peyrot, W J, Qian, Y, Raitakari, O, Rueedi, R, Salvi, E, Schmidt, B, Schraut, K E, Shi, J, Smith, A V, Poot, R A, St Pourcain, B, Teumer, A, Thorleifsson, G, Verweij, N, Vuckovic, D, Wellmann, J, Westra, H-J, Yang, J, Zhao, W, Zhu, Z, Alizadeh, B Z, Amin, N, Bakshi, A, Baumeister, S E, Biino, G, Bonnelykke, K, Boyle, P A, Campbell, H, Cappuccio, F P, Davies, G, De Neve, J-E, Deloukas, P, Demuth, I, Ding, J, Eibich, P, Eisele, L, Eklund, N, Evans, D M, Faul, J D, Feitosa, M F, Forstner, A J, Gandin, I, Gunnarsson, B, Halldorsson, B V, Harris, T B, Heath, A C, Hocking, L J, Holliday, E G, Homuth, G, Horan, M A, Hottenga, J-J, de Jager, P L, Joshi, P K, Jugessur, A, Kaakinen, M A, Kahonen, M, Kanoni, S, Keltigangas-Jarvinen, L, Kiemeney, L A L M, Kolcic, I, Koskinen, S, Kraja, A T, Kroh, M, Kutalik, Z, Latvala, A, Launer, L J, Lebreton, M P, Levinson, D F, Lichtenstein, P, Lichtner, P, Liewald, D C M, Loukola, A, Madden, P A, Magi, R, Maki-Opas, T, Marioni, R E, Marques-Vidal, P, Meddens, G A, McMahon, G, Meisinger, C, Meitinger, T, Milaneschi, Y, Milani, L, Montgomery, G W, Myhre, R, Nelson, C P, Nyholt, D R, Ollier, W E R, Palotie, A, Paternoster, L, Pedersen, N L, Petrovic, K E, Porteous, D J, Raikkonen, K, Ring, S M, Robino, A, Rostapshova, O, Rudan, I, Rustichini, A, Salomaa, V, Sanders, A R, Sarin, A-P, Schmidt, H, Scott, R J, Smith, B H, Smith, J A, Staessen, J A, Steinhagen-Thiessen, E, Strauch, K, Terracciano, A, Tobin, M D, Ulivi, S, Vaccargiu, S, Quaye, L, van Rooij, F J A, Venturini, C, Vinkhuyzen, A A E, Volker, U, Volzke, H, Vonk, J M, Vozzi, D, Waage, J, Ware, E B, Willemsen, G, Attia, J R, Bennett, D A, Berger, K, Bertram, L, Bisgaard, H, Boomsma, D I, Borecki, I B, Bultmann, U, Chabris, C F, Cucca, F, Cusi, D, Deary, I J, Dedoussis, G V, van Duijn, C M, Eriksson, J G, Franke, B, Franke, L, Gasparini, P, Gejman, P V, Gieger, C, Grabe, H-J, Gratten, J, Groenen, P J F, Gudnason, V, van der Harst, P, Hayward, C, Hinds, D A, Hoffmann, W, Hyppnen, E, Iacono, W G, Jacobsson, B, Jarvelin, M-R, Jockel, K-H, Kaprio, J, Kardia, S L R, Lehtimaki, T, Lehrer, S F, Magnusson, P K E, Martin, N G, McGue, M, Metspalu, A, Pendleton, N, Penninx, B W J H, Perola, M, Pirastu, N, Pirastu, M, Polasek, O, Posthuma, D, Power, C, Province, M A, Samani, N J, Schlessinger, D, Schmidt, R, Sorensen, T I A, Spector, T D, Stefansson, K, Thorsteinsdottir, U, Thurik, A R, Timpson, N J, Tiemeier, H, Tung, J Y, Uitterlinden, A G, Vitart, V, Vollenweider, P, Weir, D R, Wilson, J F, Wright, A F, Conley, D C, Krueger, R F, Smith, G D, Hofman, A, Laibson, D I, Medland, S E, Meyer, M N, Yang, J, Johannesson, M, Visscher, P M, Esko, T, Koellinger, P D, Cesarini, D & Benjamin, D J 2016, ' Genome-wide association study identifies 74 loci associated with educational attainment ', Nature, vol. 533, no. 7604, pp. 539-+ . https://doi.org/10.1038/nature17671
Nature, 533(7604), 539-+. Nature Publishing Group
Nature, 533, 7604, pp. 539-42
Okbay, A, St Pourcain, B, Evans, D, McMahon, G, Paternoster, L, Ring, S, Sorensen, T, Timpson, N, Davey Smith, G, Visscher, P M, Koellinger, P D, Cesarini, D & Benjamin, D J 2016, ' Genome-wide association study identifies 74 loci associated with educational attainment ', Nature, vol. 533, no. 7604, pp. 539-542 . https://doi.org/10.1038/nature17671
ISSN: 0028-0836
1476-4687
1476-4679
DOI: 10.1038/nature17671
Popis: Contains fulltext : 167137.pdf (Publisher’s version ) (Closed access) Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
Databáze: OpenAIRE
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